NUMERICAL STUDY OF HEMODYNAMICS OF LUMPED-PARAMETER MODEL FOR LOWER LIMB AMPUTEE

被引：0
|
作者：
Diao J.-J. [1 ,2 ]
Jiang W.-T. [1 ,2 ]
Li Z.-Y. [1 ,2 ]
Wei J.-R. [1 ,2 ]
Li X. [1 ,2 ]
Min L. [1 ,2 ]
机构：
[1] Department of Mechanical Science and Engineering, Sichuan University, Chengdu
[2] Biomechanical Engineering Laboratory, Sichuan University, Chengdu
来源：
Gongcheng Lixue/Engineering Mechanics | 2023年 / 40卷 / 04期
关键词：
cardiovascular disease; hemodynamics; lower limb amputation; lumped parameter model; peripheral impedance;
D O I：
10.6052/j.issn.1000-4750.2021.10.0755
中图分类号：
学科分类号：
摘要：
Although lower limb amputation has been identified as a possible risk factor of cardiovascular disease, the underlying biomedical mechanisms are not completely understood. The purpose of this study was to examine the cardiovascular hemodynamic status of lower limb amputees at different postoperative periods and life status to evaluate the impact of abnormal hemodynamics on cardiovascular system. In this paper, a centralized parameter model of the cardiovascular system with lower limb arteries was established to simulate three common conditions of amputation patients, i.e., postoperation, postoperation residual limb atrophy and postoperation both limb atrophy. The diameter of lower limb artery measured by ultrasound in 7 patients with lower limb amputation was used as the reference for parameter setting of the model. By comparing the blood pressure and blood flow waveform of the normal person model and the lower limb amputation model, we found that the amplitude of the systolic and diastolic blood pressure increased after amputation, and the peak value of the arterial flow in the abdominal aorta and below decreased significantly. In postoperation residual limb atrophy and postoperation both limb atrophy, the peak blood pressure in the central aorta increased during diastole. Such abnormal hemodynamic changes may be a risk factor of cardiovascular diseases such as hypertension and ventricular hypertrophy in lower limb amputees. The centralized parameter model established in this paper provides the change rule of hemodynamics after amputation, which can provide theoretical guidance of rehabilitation treatment and cardiovascular disease prevention of amputation patients in the future. © 2023 Tsinghua University. All rights reserved.
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页码：233 / 342
页数：109
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