New coumarin glucopyranosides from roots of Angelica dahurica

Objective: To investigate the chemical constituents from the roots of Angelica dahurica.Methods: The chemical constituents were isolated and purified by AB-8 macroporous adsorption resin and Sephadex LH-20 column as well as semi-preparative reversed phase HPLC.The chemical structures were identified by spectral data.Results: Ten compounds were isolated and identified as xanthoarnol-3-O-β-d-glucopyranoside(1),angedahuricoside A(2),angedahuricoside B(3),isofraxidin-7-O-β-d-glucopyranoside(4),fraxidin-8-O-β-d-glucopyranoside(5),(-)-marmesinin(6),(2 S,3 R)-3-hydroxymarmesinin(7),hyuganoside V(8),daucosterol(9),and sucrose(10).Conclusion: Compounds 1 –3 are new ones and compounds 4 –6 and 8 are obtained from title plant for the first time.