FDA approved fluorine-containing drugs in 2023

被引：0

作者：

Qian Wang ^{[1
]}

Yeping Bian ^{[2
]}

Gagan Dhawan ^{[3
]}

Wei Zhang ^{[4
]}

Alexander ESorochinsky ^{[5
]}

Ata Makarem ^{[6
]}

Vadim ASoloshonok ^{[7
,8
]}

Jianlin Han ^{[1
]}

机构：

[1] Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University

[2] Jiangsu Province Geriatric Hospital

[3] School of Allied Medical Sciences, Delhi Skill and Entrepreneurship University, and Department of Biomedical Science, Acharya Narendra Dev College,University of Delhi

[4] Department of Chemistry, University of Massachusetts Boston

[5] VPKukhar Institute of Bioorganic Chemistry and Petrochemistry, The National Academy of Sciences of Ukraine

[6] Department of Chemistry, University of Hamburg

[7] Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU

[8] IKERBASQUE, Basque Foundation for

来源：

Chinese Chemical Letters | 2024年 / 35卷 / 11期

关键词：

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

摘要：

This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023. These small molecule drugs represent such therapeutic areas as cancer, neuromuscular disorder, immunodeficiency, virology, and infectious diseases. Medicinal chemistry discovery,biological activity, and synthetic routes have been discussed for each drug. Also, new trends in structural positioning, functionality, and degree of fluorination are discussed. Besides fluorination, the importance of amino acid residues and chirality in the design of new pharmaceuticals is highlighted.

引用

页码：138 / 149

页数：12

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