Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution

被引：0

作者：

Zhaoshi Bao ^{[1
,2
,3
]}

Yongzhi Wang ^{[1
,2
]}

Qiangwei Wang ^{[1
]}

Shengyu Fang ^{[1
]}

Xia Shan ^{[1
,4
]}

Jiguang Wang ^{[5
]}

Tao Jiang ^{[1
,2
,6
,7
]}

机构：

[1] Beijing Neurosurgical Institute, Capital Medical University

[2] Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University

[3] Division of Life Science, Hong Kong University of Science and Technology

[4] Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University

[5] Divison of Life Science, Department of Chemical and Biological Engineering,Center for Systems Biology and Human Health, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology

[6] China National Clinical Research Center for Neurological Diseases

[7] Center of Brain Tumor, Beijing Institute for Brain Disorders

来源：

Frontiers of Medicine | 2021年 / 15卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R739.41 [颅内肿瘤及脑肿瘤];

学科分类号：

100214 ;

摘要：

Glioma is the most common lethal tumor of the human brain. The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 months. The World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and glioblastomas. Unlike primary glioblastoma that usually develop de novo in the elderly, secondary glioblastoma enriched with an isocitrate dehydrogenase mutant typically progresses from lower-grade glioma within 5–10 years from the time of diagnosis. Based on various evolutional trajectories brought on by clonal and subclonal alterations, the evolution patterns of glioma vary according to different theories. Some important features distinguish the normal brain from other tissues, e.g., the composition of the microenvironment around the tumor cells, the presence of the blood-brain barrier, and others. The underlying mechanism of glioma recurrence and evolution patterns of glioma are different from those of other types of cancer. Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment. However, the detailed reasons for the progression and recurrence of glioma remain controversial. In this review, we introduce the different mechanisms involved in glioma progression, including tumor heterogeneity, the tumor microenvironment and drug resistance,and their pre-clinical implements in clinical trials. This review aimed to provide new insights into further clinical strategies for the treatment of patients with recurrent and secondary glioma.

引用

页码：551 / 561

页数：11