Human Monoclonal Antibodies as Candidate Therapeutics Against Emerging Viruses and HIV-1

被引：0
|
作者：
Zhongyu Zhu [1 ]
Ponraj Prabakaran [1 ,2 ]
Weizao Chen [1 ]
Christopher CBroder [3 ]
Rui Gong [4 ]
Dimiter SDimitrov [1 ]
机构：
[1] Protein Interactions Group, National Cancer Institute, National Institutes of Health
[2] Basic Research Program, Science Applications International Corporation-Frederick, Inc
[3] Department of Microbiology and Immunology, Uniformed Services University
[4] Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of
来源：
Virologica Sinica | 2013年 / 28卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
More than 40 monoclonal antibodies (mAbs) have been approved for a number of disease indications with only one of these (Synagis) - for a viral disease, and not for therapy but for prevention. However, in the last decade novel potent mAbs have been discovered and characterized with potential as therapeutics against viruses of major importance for public health and biosecurity including Hendra virus (HeV), Nipah virus (NiV), severe acute respiratory syndrome coronavirus (SARS-CoV), Ebola virus (EBOV), West Nile virus (WNV), influenza virus (IFV) and human immunodeficiency virus type 1 (HIV-1). Here, we review such mAbs with an emphasis on antibodies of human origin, and highlight recent results as well as technologies and mechanisms related to their potential as therapeutics.
引用
收藏
页码：71 / 80
页数：10
相关论文
共 50 条
  • [1] Human Monoclonal Antibodies as Candidate Therapeutics Against Emerging Viruses and HIV-1
    Zhongyu Zhu
    Ponraj Prabakaran
    Weizao Chen
    Christopher C.Broder
    Rui Gong
    Dimiter S.Dimitrov
    Virologica Sinica, 2013, (02) : 71 - 80
  • [2] Human monoclonal antibodies as candidate therapeutics against emerging viruses
    Jin, Yujia
    Lei, Cheng
    Hu, Dan
    Dimitrov, Dimiter S.
    Ying, Tianlei
    FRONTIERS OF MEDICINE, 2017, 11 (04) : 462 - 470
  • [3] Human monoclonal antibodies as candidate therapeutics against emerging viruses
    Yujia Jin
    Cheng Lei
    Dan Hu
    Dimiter S. Dimitrov
    Tianlei Ying
    Frontiers of Medicine, 2017, 11 : 462 - 470
  • [4] Human Monoclonal Antibodies Against HIV and Emerging Viruses
    Dimitrov, Dimiter S.
    NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, NIH, VOL 1: FRONTIERS IN RESEARCH, 2008, : 299 - 308
  • [5] PILOT PRODUCTION OF HUMAN MONOCLONAL-ANTIBODIES AGAINST HIV-1
    JUNGBAUER, A
    STEINDL, F
    GRUNOW, R
    PORSTMANN, T
    ERNST, W
    PURTSCHER, M
    REITER, M
    TAUER, C
    WENISCH, E
    KATINGER, H
    ZEITSCHRIFT FUR KLINISCHE MEDIZIN-ZKM, 1990, 45 (04): : 351 - 354
  • [6] PRODUCTION OF HUMAN MONOCLONAL-ANTIBODIES AGAINST HIV-1 PEPTIDES
    BONGERTZ, V
    WIGZELL, H
    ROSSI, P
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1991, 24 (08) : 815 - 818
  • [7] Candidate Antibody-Based Therapeutics Against HIV-1
    Rui Gong
    Weizao Chen
    Dimiter S. Dimitrov
    BioDrugs, 2012, 26 : 143 - 162
  • [8] Candidate Antibody-Based Therapeutics Against HIV-1
    Gong, Rui
    Chen, Weizao
    Dimitrov, Dimiter S.
    BIODRUGS, 2012, 26 (03) : 143 - 162
  • [9] Monoclonal Antibody-Based Candidate Therapeutics Against HIV Type 1
    Chen, Weizao
    Dimitrov, Dimiter S.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2012, 28 (05) : 425 - 434
  • [10] CHARACTERIZATION AND LARGE PRODUCTION OF HUMAN MONOCLONAL-ANTIBODIES AGAINST THE HIV-1 ENVELOPE
    BOYER, V
    BROLY, H
    SOUCHE, S
    MADAULE, P
    ROSSIER, J
    ZAGURY, D
    DESGRANGES, C
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1991, 83 (03): : 452 - 459
12345