Pleiotropic Effects of Herbs Characterized with Blood-Activating and Stasis-Resolving Functions on Angiogenesis

被引：0

作者：

陶丽 ^{[1
]}

王生 ^{[1
]}

赵杨 ^{[1
]}

王爱云 ^{[1
,2
]}

张蕾 ^{[3
]}

阮君山 ^{[4
]}

范方田 ^{[5
]}

刘玉萍 ^{[1
]}

李尧 ^{[1
]}

岳志强 ^{[1
]}

钱文慧 ^{[6
]}

陈文星 ^{[1
,2
]}

陆茵 ^{[1
,2
]}

机构：

[1] Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine

[2] Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine

[3] Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University

[4] Fujian Provincial Hospital, Clinical College of Fujian Medical University

[5] Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine

[6] Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine

来源：

Chinese Journal of Integrative Medicine | 2016年 / 22卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

Accumulative evidences have underpinned the nature candidates from Chinese medicine(CM), particularly CM served as blood activating and stasis resolving(BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that(1) BASR-CM might emphasize on a balanced multi-cytokines network interaction;(2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis;(3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.

引用

页码：795 / 800

页数：6

共 14 条

[1] Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1α [J].

Lin, Chiu-Mei ;

Chiu, Jen-Hwey ;

Wu, I-Hsing ;

Wang, Bao-Wei ;

Pan, Chun-Ming ;

Chen, Yen-Hsu .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2010, 21 (07) :627-633

[2]

Danshensu has anti-tumor activity in B16F10 melanoma by inhibiting angiogenesis and tumor cell invasion.[J].Li-juan Zhang;Lei Chen;Yin Lu;Jia-ming Wu;Bo Xu;Zhi-guang Sun;Shi-zhong Zheng;Ai-yun Wang.European Journal of Pharmacology.2010, 2

[3] Acidic mucopolysaccharide from holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro [J].

Zhang, Weiwei ;

Lu, Yin ;

Xu, Bo ;

Wu, Jiaming ;

Zhang, Lijuan ;

Gao, Ming ;

Zheng, Shizhong ;

Wang, Aiyun ;

Zhang, Changbin ;

Chen, Lei ;

Lei, Na .

CANCER BIOLOGY & THERAPY, 2009, 8 (15) :1489-1499

[4] Hypoxia-Regulated Angiogenic Inhibitors [J].

Messmer-Blust, Angela ;

An, Xiaojin ;

Li, Jian .

TRENDS IN CARDIOVASCULAR MEDICINE, 2009, 19 (08) :252-256

[5]

Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect.[J].Yu-Jen Chen;Yin-Meng Tsai;Cheng-Deng Kuo;Kuo-Lung Ku;Huei-Sian Shie;Hui-Fen Liao.Life Sciences.2009, 17

[6] Ligustrazine inhibits B16F10 melanoma metastasis and suppresses angiogenesis induced by Vascular Endothelial Growth Factor [J].

Chen, Lei ;

Lu, Yin ;

Wu, Jia-ming ;

Xu, Bo ;

Zhang, Li-juan ;

Gao, Ming ;

Zheng, Shi-zhong ;

Wang, Ai-yun ;

Zhang, Chang-bin ;

Zhang, Wei-wei ;

Lei, Na .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 386 (02) :374-379

[7]

Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization.[J].Dai Fukumura;Rakesh K. Jain.Microvascular Research.2007, 2

[8]

Arteriogenesis versus angiogenesis: similarities and differences.[J].M.Heil;InkaEitenmüller;T.Schmitz‐Rixen;W.Schaper.Journal of Cellular and Molecular Medicine.2007, 1

[9] Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1 [J].

Bae, Moon-Kyoung ;

Kim, Se-Hee ;

Jeong, Joo-Won ;

Lee, You Mie ;

Kim, Hae-Sun ;

Kim, Su-Ryun ;

Yun, Il ;

Bae, Soo-Kyung ;

Kim, Kyu-Won .

ONCOLOGY REPORTS, 2006, 15 (06) :1557-1562

[10]

Effects of Blood-Activating and Stasis-Resolving Drugs on Tumor Formation and Metastasis.[J].钱彦方;王晓静;段树民;.Journal of Traditional Chinese Medicine.2009, 04

← 1 2 →