Structures of a P4-ATPase lipid flippase in lipid bilayers

被引：0
|
作者：
Yilin He [1 ,2 ]
Jinkun Xu [1 ]
Xiaofei Wu [1 ]
Long Li [1 ]
机构：
[1] State Key Laboratory of Membrane Biology, Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University
[2] Academy for Advanced Interdisciplinary Studies, Peking
来源：
Protein & Cell | 2020年 / 11卷 / 06期
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D O I：
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中图分类号：
Q26 [细胞生物化学];
学科分类号：
摘要：
<正>Dear Editor,Phospholipid molecules are unevenly distributed in membrane bilayers of eukaryotic cells.Phosphatidylethanolamine(PE) and phosphatidylserine (PS) are concentrated in the cytoplasmic leaflet,whereas phosphatidylcholine (PC) is enriched in the exoplasmic leaflet (lumenal or extracellular leaflet)(van Meer et al.2008).Type 4 P-type ATPases (P4-ATPases) are the phospholipid flippases which move specific lipids from the exoplasmic leaflet to the cytoplasmicleaflet.P4-ATPases belong to the P-type ATPase family.
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页码：458 / 463
页数：6
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