Epigenetic changes associated with oocyte aging

被引：0
|
作者：
SCHATTEN Heide
机构：
[1] DepartmentofVeterinaryPathobiology,UniversityofMissouri,Columbia,MO,USA
来源：
Science China(Life Sciences) | 2012年 / 55卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R321 [人体胚胎学（人体胎生学、发生学）];
学科分类号：
071008 ;
摘要：
It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age.Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process.Here,we review the epigenetic alterations,mainly focused on DNA methylation,histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age.Furthermore,we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.
引用
收藏
页码：670 / 676
页数：7
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