Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

被引：0

作者：

Laetitia Aubry ^{[1
]}

Timothy Barrett ^{[2
,3
]}

Sovan Sarkar ^{[2
]}

机构：

[1] I-STEM,CECS,Corbeil-Essonnes,France (Aubry L) Universite Paris-Saclay,Université d'Evry,INS ERM,I-STEM

[2] Institute of Cancer and Genomic Sciences,Institute of Biomedical Research,College of Medical and Dental Sciences,University of Birmingham

[3] Department of Endocrinology,Birmingham Women's and Children's Hospital

来源：

Neural Regeneration Research | 2025年 / 20卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

<正>Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the "powerhouse" of the cell.Nevertheless,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca2+) homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,and β-oxidation of fatty acids.

引用

页码：2587 / 2588

页数：2