Role of short-chain fatty acids in host physiology

被引：0

作者：

Mingyue Liu ^{[1
]}

Yubo Lu ^{[2
]}

Guoyu Xue ^{[1
]}

Le Han ^{[3
]}

Hanbing Jia ^{[4
]}

Zi Wang ^{[4
]}

Jia Zhang ^{[5
]}

Peng Liu ^{[6
]}

Chaojuan Yang ^{[7
]}

Yingjie Zhou ^{[8
]}

机构：

[1] Stem Cell Storage Center, Hebei Reproductive Health Hospital, Hebei Women and Children's Health Hospital, Hebei Research Institute For Reproductive Health

[2] School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University

[3] Prevention Health Section, Hebei Reproductive Health Hospital, Hebei Women and Children's Health Hospital, Hebei Research Institute For Reproductive Health

[4] Department of Medical Imaging, Hebei Reproductive Health Hospital, Hebei Women and Children's Health Hospital, Hebei Research Institute For Reproductive Health

[5] Department of Obstetrical, Hebei Reproductive Health Hospital, Hebei Women and Children's Health Hospital, Hebei Research Institute For Reproductive Health

[6] Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Hebei Women and Children's Health Hospital, Hebei Research Institute For Reproductive Health

[7] Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University

[8] Department of Obstetrics and Gynecology, Hebei Reproductive Health Hospital, Hebei Women and Children's Health Hospital, Hebei Research Institute For Reproductive Health

来源：

Animal Models and Experimental Medicine | 2024年 / 7卷 / 05期

关键词：

D O I：

暂无

中图分类号：

R33 [人体生理学];

学科分类号：

1001 ;

摘要：

Short-chain fatty acids(SCFAs) are major metabolites produced by the gut microbiota through the fermentation of dietary fiber, and they have garnered significant attention due to their close association with host health. As important mediators between the gut microbiota and the host, SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics, activating G protein-coupled receptors, and inhibiting pathogenic microbial infections. This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health, enhancing energy metabolism, mitigating diseases such as cancer, obesity, and diabetes, modulating the gut-brain axis and gut-l ung axis,and promoting bone health.

引用

页码：641 / 652

页数：12