Impact of caffeic acid on aluminium chloride-induced dementia in rats

被引：72

作者：

Khan, Kafeel A. ^{[1
]}

Kumar, Nitesh ^{[1
]}

Nayak, Pawan G. ^{[1
]}

Nampoothiri, Madhavan ^{[1
]}

Shenoy, Rekha R. ^{[1
]}

Krishnadas, Nandakumar ^{[1
]}

Rao, C. Mallikarjuna ^{[1
]}

Mudgal, Jayesh ^{[1
]}

机构：

[1] Manipal Univ, Manipal Coll Pharmaceut Sci, Dept Pharmacol, Manipal 576104, Karnataka, India

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 2013年 / 65卷 / 12期

关键词：

acetylcholinesterase; aluminium chloride; caffeic acid; Morris water maze; oxidative stress; PHENETHYL ESTER; OXIDATIVE DAMAGE; BRAIN; ACETYLCHOLINESTERASE; NEUROTOXICITY; GLUTATHIONE; INHIBITION; PROTECTION; TOXICITY; TAU;

D O I：

10.1111/jphp.12126

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ObjectiveLiterature favours the in vitro neuroprotective role of caffeic acid, a naturally derived polyphenolic compound. This study was aimed to investigate the role of caffeic acid in experimental model of Alzheimer's disease. MethodsFirstly, caffeic acid was tested for in vitro anticholinesterase potential using rat brain homogenate. Later, in vivo antidementia activity of caffeic acid was assessed against aluminium chloride (AlCl3)-induced dementia in rats. Behavioural (Morris water maze test) and brain biochemical parameters (acetylcholinesterase (AChE), catalase, glutathione-S-transferase (GST) activity, glutathione (GSH) and nitrite levels) were assessed to correlate the cognitive function with cholinergic transmission and oxidative stress. Key findingsRats administered with caffeic acid showed improved cognitive function in Morris water maze test. The antidementia activity of caffeic acid was confirmed by the reduction in brain AChE activity and nitrite levels. Further, caffeic acid corrected the diminished level of antioxidant enzymes such as catalase, GSH and GST in brain. ConclusionThese findings suggest the antidementia activity of caffeic acid against AlCl3-induced dementia in rats. The outcome of present study offers a wider scope to screen caffeic acid against neurodegeneration associated disorders.

引用

页码：1745 / 1752

页数：8

共 43 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2]

Aly HF, 2011, ACTA BIOCHIM POL, V58, P513

[3] Effects of caffeic acid on behavioral parameters and on the activity of acetylcholinesterase in different tissues from adult rats [J].

Anwar, Javed ;

Spanevello, Roselia Maria ;

Thome, Gustavo ;

Stefanello, Naiara ;

Schmatz, Roberta ;

Gutierres, Jessie ;

Vieira, Juliano ;

Baldissarelli, Jucimara ;

Carvalho, Fabiano Barbosa ;

Melgarejo da Rosa, Michelle ;

Rubin, Maribel Antonello ;

Fiorenza, Amanda ;

Morsch, Vera Maria ;

Chitolina Schetinger, Maria Rosa .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2012, 103 (02) :386-394

[4] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J].

BEHL, C ;

DAVIS, JB ;

LESLEY, R ;

SCHUBERT, D .

CELL, 1994, 77 (06) :817-827

[5] The potential role of aluminium in Alzheimer's disease [J].

Campbell, A .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 :17-20

[6] Study on the interaction of copper-zinc superoxide dismutase with aluminum ions by electrochemical and fluorescent method [J].

Di, Junwei ;

Yao, Kaian ;

Han, Weiying ;

Bi, Shuping .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2006, 65 (3-4) :896-900

[7] Inflammation occurs early during the Aβ deposition process in TgCRND8 mice [J].

Dudal, S ;

Krzywkowski, P ;

Paquette, J ;

Morissette, C ;

Lacombe, D ;

Tremblay, P ;

Gervais, F .

NEUROBIOLOGY OF AGING, 2004, 25 (07) :861-871

[8] DIVERGENT REGULATION OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN TISSUES OF THE RAT [J].

EDWARDS, JA ;

BRIMIJOIN, S .

JOURNAL OF NEUROCHEMISTRY, 1982, 38 (05) :1393-1403

[9] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[10] The neuroprotective effects of caffeic acid phenethyl ester (CAPE) in the hippocampal formation of cigarette smoke exposed rabbits [J].

Eser, Olcay ;

Cosar, Murat ;

Sahin, Onder ;

Mollaoglu, Hakan ;

Sezer, Murat ;

Yaman, Mehmet ;

Songur, Ahmet .

PATHOLOGY, 2007, 39 (04) :433-437

← 1 2 3 4 5 →