Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology

被引：8

作者：

Sun, Pan ^{[1
,2
]}

He, Zhengbo ^{[1
]}

Li, Anqi ^{[1
]}

Yang, Jie ^{[1
]}

Zhu, Yalin ^{[1
]}

Cai, Yue ^{[1
]}

Ma, Ting ^{[3
]}

Ma, Shaohua ^{[2
]}

Guo, Tengfei ^{[1
,4
]}

机构：

[1] Inst Biomed Engn, Shenzhen Bay Lab, 5 Kelian Rd, Shenzhen 518132, Peoples R China

[2] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch SIGS, Shenzhen, Peoples R China

[3] Harbin Inst Technol Shenzhen, Sch Elect & Informat Engn, Shenzhen, Peoples R China

[4] Peking Univ, Shenzhen Grad Sch, Inst Biomed Engn, Shenzhen, Peoples R China

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 10期

基金：

中国国家自然科学基金;

关键词：

age; Alzheimer's disease; cortical mean diffusivity; suspected non-Alzheimer's pathophysiology; vascular disease; NEURODEGENERATION; ACCUMULATION; ASSOCIATION; DECLINE; TAU;

D O I：

10.1002/alz.14176

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: The spatial and temporal patterns of cortical mean diffusivity (cMD), as well as its association with Alzheimer's disease (AD) and suspected non-Alzheimer's pathophysiology (SNAP), are not yet fully understood. METHODS: We compared baseline (n = 617) and longitudinal changes (n = 421) of cMD, cortical thickness, and gray matter volume and their relations to vascular risk factors, amyloid beta (A beta), and tau positron emission tomography (PET), and longitudinal cognitive decline in A beta PET negative and positive older adults. RESULTS: cMD increases were more sensitive to detecting brain structural alterations than cortical thinning and gray matter atrophy. Tau-related cMD increases partially mediated A beta-related cognitive decline in AD, whereas vascular disease-related increased cMD levels substantially mediated age-related cognitive decline in SNAP. DISCUSSION: These findings revealed the dynamic changes of microstructural and macrostructural indicators and their associations with AD and SNAP, providing novel insights into understanding upstream and downstream events of cMD in neurodegenerative disease.

引用

页码：7048 / 7061

页数：14

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