Pd-catalyzed S-glycosylation of cysteine-containing peptides at room temperature

被引：1

作者：

Shen, Linhua ^{[1
]}

Le Bideau, Franck ^{[1
]}

Chen, Gong ^{[2
,3
]}

Messaoudi, Samir ^{[1
,4
]}

机构：

[1] Univ Paris Saclay, CNRS, BioCIS, F-91400 Orsay, France

[2] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China

[3] Nankai Univ, Inst Elemento Organ Chem, Coll Chem, Tianjin 300071, Peoples R China

[4] Inst Polytech Paris, Ecole Polytech, Lab Synth Organ, CNRS,ENSTA, Palaiseau, France

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 22期

关键词：

PROTEIN GLYCOSYLATION; SUBLANCIN; 168; 1-THIOSUGARS; TREHALOSE; ARYL;

D O I：

10.1039/d4qo01389a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study reports the synthesis of thioglycopeptides through a Pd-catalyzed coupling of cysteine-containing peptides with iodoglycals. The scope of this reaction is demonstrated by the use of a variety of protected and unprotected peptides as well as other thiol nucleophiles including thiosugars, thioalkyls, and thiophenols. This approach offers an efficient entry to S-linked glycopeptides and oligosaccharides.

引用

页码：6347 / 6352

页数：6

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