Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration

被引：3

作者：

England-Mason, Gillian ^{[1
,2
]}

Merrill, Sarah M. ^{[3
,4
,5
]}

Liu, Jiaying ^{[6
]}

Martin, Jonathan W. ^{[7
]}

MacDonald, Amy M. ^{[8
]}

Kinniburgh, David W. ^{[6
,8
]}

Gladish, Nicole ^{[4
,5
]}

Macisaac, Julia L. ^{[4
,5
]}

Giesbrecht, Gerald F. ^{[1
,2
,9
,10
]}

Letourneau, Nicole ^{[1
,2
,10
,11
,12
,13
]}

Kobor, Michael S. ^{[4
,5
,14
]}

Dewey, Deborah ^{[1
,2
,10
,13
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB T2N 1N4, Canada

[2] Univ Calgary, Alberta Childrens Hosp, Res Inst, Owerko Ctr, Calgary, AB T2N 1N4, Canada

[3] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02903 USA

[4] Univ British Columbia, British Columbia Childrens Hosp, Res Inst, Dept Med Genet, Vancouver, BC V6T 1Z4, Canada

[5] Ctr Mol Med & Therapeut, Vancouver, BC V6H 0B3, Canada

[6] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2R3, Canada

[7] Stockholm Univ, Dept Environm Sci, Sci Life Lab, S-11419 Stockholm, Sweden

[8] Univ Calgary, Alberta Ctr Toxicol, Calgary, AB T2N 1N4, Canada

[9] Univ Calgary, Fac Arts, Dept Psychol, Calgary, AB T2N 1N4, Canada

[10] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB T2N 1N4, Canada

[11] Univ Calgary, Fac Nursing, Calgary, AB T2N 1N4, Canada

[12] Univ Calgary, Cumming Sch Med, Dept Psychiat, Calgary, AB T2N 1N4, Canada

[13] Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada

[14] Canadian Inst Adv Res CIFAR, Program Child & Brain Dev, Toronto, ON M5G 1M1, Canada

来源：

EPIGENOMES | 2024年 / 8卷 / 03期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

bisphenol A; phthalates; DNA methylation; epigenetic clock; developmental origins of health and disease; APrON; DNA METHYLATION; PREGNANT-WOMEN; A EXPOSURE; DEVELOPMENTAL ORIGINS; REGRESSION; HEALTH; ALTERNATIVES; POPULATION; METABOLISM; PATTERNS;

D O I：

10.3390/epigenomes8030031

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We examined whether prenatal exposure to two classes of endocrine-disrupting chemicals (EDCs) was associated with infant epigenetic age acceleration (EAA), a DNA methylation biomarker of aging. Participants included 224 maternal-infant pairs from a Canadian pregnancy cohort study. Two bisphenols and 12 phthalate metabolites were measured in maternal second trimester urines. Buccal epithelial cell cheek swabs were collected from 3 month old infants and DNA methylation was profiled using the Infinium MethylationEPIC BeadChip. The Pediatric-Buccal-Epigenetic tool was used to estimate EAA. Sex-stratified robust regressions examined individual chemical associations with EAA, and Bayesian kernel machine regression (BKMR) examined chemical mixture effects. Adjusted robust models showed that in female infants, prenatal exposure to total bisphenol A (BPA) was positively associated with EAA (B = 0.72, 95% CI: 0.21, 1.24), and multiple phthalate metabolites were inversely associated with EAA (Bs from -0.36 to -0.66, 95% CIs from -1.28 to -0.02). BKMR showed that prenatal BPA was the most important chemical in the mixture and was positively associated with EAA in both sexes. No overall chemical mixture effects or male-specific associations were noted. These findings indicate that prenatal EDC exposures are associated with sex-specific deviations in biological aging, which may have lasting implications for child health and development.

引用

页数：19

共 96 条

[1] Age-associated DNA methylation in pediatric populations [J].