The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity

被引：0

作者：

Goldfield, Gary S. ^{[1
,2
,3
,4
]}

Cameron, Jameason D. ^{[5
]}

Sigal, Ronald J. ^{[3
,6
,7
]}

Kenny, Glen P. ^{[3
,7
]}

Prud'homme, Denis ^{[3
,8
]}

Ngu, Mathew ^{[3
]}

Alberga, Angela S. ^{[9
]}

Doucette, Steve ^{[10
]}

Goldfield, Diana B. ^{[11
]}

Tulloch, Heather ^{[12
]}

Thai, Helen ^{[1
,4
,13
]}

Simas, Kevin R. ^{[1
,14
]}

Walsh, Jeremy ^{[15
]}

机构：

[1] Childrens Hosp Eastern Ontario Res Inst, Hlth Act Living & Obes Res Grp, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

[2] Univ Ottawa, Dept Pediat, Ottawa, ON, Canada

[3] Univ Ottawa, Sch Human Kinet, Ottawa, ON, Canada

[4] Carleton Univ, Dept Psychol, Ottawa, ON, Canada

[5] Childrens Hosp Eastern Ontario, Dept Pharm, Ottawa, ON, Canada

[6] Univ Calgary, Cumming Sch Med, Dept Med Cardiac Sci & Community Hlth Sci, Calgary, AB, Canada

[7] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada

[8] Univ Moncton, Moncton, NB, Canada

[9] Concordia Univ, Dept Exercise Sci, Montreal, PQ, Canada

[10] Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS, Canada

[11] Queens Univ, Life Sci, Kingston, ON, Canada

[12] Univ Ottawa, Heart Inst, Div Cardiac Prevent & Rehabil, Ottawa, ON, Canada

[13] McGill Univ, Dept Psychol, Montreal, PQ, Canada

[14] Carleton Univ, Dept Neurosci, Ottawa, ON, Canada

[15] McMaster Univ, Dept Kinesiol, Hamilton, ON, Canada

来源：

PHYSIOLOGICAL REPORTS | 2024年 / 12卷 / 13期

基金：

加拿大健康研究院;

关键词：

brain derived-neurotrophic factor (BDNF); health-related quality of life (HRQoL); obesity; polymorphism; youth; NEUROTROPHIC FACTOR BDNF; ACTIVITY-DEPENDENT SECRETION; VAL(66)MET POLYMORPHISM; HUMAN-MEMORY; BRAIN; CHILDREN; ASSOCIATION; METAANALYSIS; DEPRESSION; DISORDERS;

D O I：

10.14814/phy2.16140

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether carriers of the BDNF Val66met polymorphism Met-alleles (A/A or G/A) differed from noncarriers (G/G) on HRQoL. The participants were 187 adolescents with obesity. Ninety-nine youth were carriers of the homozygous Val/Val (G/G) alleles, and 88 were carriers of the Val/Met (G/A) or Met/Met (A/A) alleles. Blood samples were drawn in the morning after an overnight fast for genotyping. HRQoL was measured using the Pediatric-Quality of Life core version. Compared to carriers of the Val66Met Val (G/G) alleles, carriers of the Met-Alleles reported significantly higher physical -HRQoL (p = 0.02), school-related HRQoL, (p = 0.05), social-related HRQoL (p = 0.05), and total HRQoL (p = 0.03), and a trend for Psychosocial-HRQoL. Research is needed to confirm our findings and determine whether carriers of the BDNF Val66Met homozygous Val (G/G) alleles may be at risk of diminished HRQoL, information that can influence interventions in a high-risk population of inactive youth with obesity.

引用

页数：10

共 58 条

[1] Healthy eating, aerobic and resistance training in youth (HEARTY): Study rationale, design and methods
Alberga, A. S.
Goldfield, G. S.
Kenny, G. P.
Hadjiyannakis, S.
Phillips, P.
Prud'homme, D.
Tulloch, H.
Gougeon, R.
Wells, G. A.
Sigal, R. J.
[J]. CONTEMPORARY CLINICAL TRIALS, 2012, 33 (04) : 839 - 847
[2] BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F
Brenè, S
Mathé, AA
[J]. MOLECULAR PSYCHIATRY, 2005, 10 (04) : 345 - 352
[3] Signaling pathways controlling activity-dependent local translation of BDNF and their localization in dendritic arbors
Baj, Gabriele
Pinhero, Vera
Vaghi, Valentina
Tongiorgi, Enrico
[J]. JOURNAL OF CELL SCIENCE, 2016, 129 (14) : 2852 - 2864
[4] Correlates of physical activity: why are some people physically active and others not?
Bauman, Adrian E.
Reis, Rodrigo S.
Sallis, James F.
Wells, Jonathan C.
Loos, Ruth J. F.
Martin, Brian W.
[J]. LANCET, 2012, 380 (9838) : 258 - 271
[5] Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine
Blakemore, Alexandra I. F.
Froguel, Philippe
[J]. YEAR IN HUMAN AND MEDICAL GENETICS: NEW TRENDS IN MENDELIAN GENETICS, 2010, 1214 : 180 - 189
[6] BRAIN-DERIVED NEUROTROPHIC FACTOR AS A MODEL SYSTEM FOR EXAMINING GENE BY ENVIRONMENT INTERACTIONS ACROSS DEVELOPMENT
Casey, B. J.
Glatt, C. E.
Tottenham, N.
Soliman, F.
Bath, K.
Amso, D.
Altemus, M.
Pattwell, S.
Jones, R.
Levita, L.
McEwen, B.
Magarinos, A. M.
Gunnar, M.
Thomas, K. M.
Mezey, J.
Clark, A. G.
Hempstead, B. L.
Lee, F. S.
[J]. NEUROSCIENCE, 2009, 164 (01) : 108 - 120
[7] Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
Chen, ZY
Patel, PD
Sant, G
Meng, CX
Teng, KK
Hempstead, BL
Lee, FS
[J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (18) : 4401 - 4411
[8] REGULATION OF NEUROPEPTIDES IN ADULT-RAT FOREBRAIN BY THE NEUROTROPHINS BDNF AND NGF
CROLL, SD
WIEGAND, SJ
ANDERSON, KD
LINDSAY, RM
NAWA, H
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (08) : 1343 - 1353
[9] The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults: a meta-analysis
Dinoff, Adam
Herrmann, Nathan
Swardfager, Walter
Lanctot, Krista L.
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2017, 46 (01) : 1635 - 1646
[10] The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis
Dinoff, Adam
Herrmann, Nathan
Swardfager, Walter
Liu, Celina S.
Sherman, Chelsea
Chan, Sarah
Lanctot, Krista L.
[J]. PLOS ONE, 2016, 11 (09):

← 1 2 3 4 5 6 →