Two Undescribed Coumarins from Notopterygium Incisum with Anti-Inflammatory Activity

被引：1

作者：

Hu, Yun-Jie ^{[1
]}

Liu, Meng-Dan ^{[1
]}

Mu, Yu-Ting ^{[1
]}

Li, Cong-Cong ^{[1
]}

Zhao, Min-Hong ^{[1
]}

Guo, Da-Le ^{[1
]}

Huang, Li-Jun ^{[2
]}

Gu, Yu-Cheng ^{[3
]}

Xue, Qing-Cai ^{[2
]}

Deng, Yun ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resource, Chengdu, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu 611137, Peoples R China

[3] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, England

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 08期

基金：

中国国家自然科学基金;

关键词：

coumarin; Notopterygium incisum; anti-inflammatory activity; PI3K/AKT pathway; EXTRACT; RHIZOMES; PATHWAY;

D O I：

10.1002/cbdv.202401093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two previously undescribed coumarins (1-2) were isolated from the root of Notopterygium incisum. The structures of new findings were elucidated by analyses of spectral evidences in HRESIMS, NMR, as well as ICD. The absolute configurations were further confirmed by chemical calculations. 1-2 exhibits obviously anti-inflammatory activity by inhibiting the expression of inflammatory mediators (COX-2, iNOS), as well as reducing the release of NO and the accumulation of ROS in cells. Western blotting analysis revealed that 2 could inhibit the PI3K/AKT pathway by reducing the expression of p-PI3K and p-AKT.

引用

页数：6

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