Impact of Statin Therapy on Diabetes Incidence: Implications for Primary Prevention

被引:2
作者
Rikhi, Rishi [1 ]
Shapiro, Michael D. [1 ]
机构
[1] Wake Forest Univ, Sch Med, Ctr Prevent Cardiovasc Dis, Sect Cardiovasc Med,Dept Internal Med, Winston Salem, NC 27157 USA
关键词
Statin; Diabetes; Primary prevention; Atherosclerosis; Cardiovascular disease; RISK; PRAVASTATIN; MELLITUS; DISEASE; WOMEN; MEN;
D O I
10.1007/s11886-024-02141-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of Review The present review aims to summarize current evidence, explore underlying mechanisms, and help guide clinicians regarding statin therapy and diabetes risk in primary prevention. Recent Findings The observational and genetic epidemiology, as well as evidence from randomized controlled trials and meta-analyses, illustrate a modest, dose-dependent increase in risk of diabetes from statin therapy. Summary Risk of new onset diabetes from statins appears to be greatest in those near the diagnostic threshold for diabetes or with diabetes risk factors prior to statin initiation. The risk of incident diabetes is vastly offset by the cardiovascular protection offered from statin therapy and should not deter guideline recommended statin initiation in primary prevention.
引用
收藏
页码:1447 / 1452
页数:6
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