A novel cell-free therapy using exosomes in the inner ear regeneration

被引：3
作者：
Amiri, Masoumeh [1 ]
Kaviari, Mohammad Amin [2 ,3 ]
Rostaminasab, Gelavizh [4 ]
Barimani, Amir [4 ]
Rezakhani, Leila [5 ,6 ]
机构：
[1] Kermanshah Univ Med Sci, Fac Med, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran
[3] Kermanshah Univ Med Sci, Universal Sci Educ & Res Network USERN Off, Kermanshah, Iran
[4] Kermanshah Univ Med Sci, Imam Khomeini & Mohammad Kermanshahi & Farabi Hosp, Clin Res Dev Ctr, Kermanshah, Iran
[5] Kermanshah Univ Med Sci, Hlth Technol Inst, Fertil & Infertil Res Ctr, Kermanshah, Iran
[6] Kermanshah Univ Med Sci, Sch Med, Dept Tissue Engn, Kermanshah, Iran
来源：
TISSUE & CELL | 2024年 / 88卷
关键词：
Exosome; Inner ear; Regeneration; Biomarker; Nanocarrier; SENSORINEURAL HEARING-LOSS; MESENCHYMAL STEM-CELLS; SIMPLEX-VIRUS INFECTION; AUDITORY HAIR-CELLS; INTERCELLULAR-COMMUNICATION; OXIDATIVE STRESS; SUPPORTING CELLS; DISEASE; FUTURE; AUTOIMMUNE;
D O I：
10.1016/j.tice.2024.102373
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Cellular and molecular alterations associated with hearing loss are now better understood with advances in molecular biology. These changes indicate the participation of distinct damage and stress pathways that are unlikely to be fully addressed by conventional pharmaceutical treatment. Sensorineural hearing loss is a common and debilitating condition for which comprehensive pharmacologic intervention is not available. The complex and diverse molecular pathology that underlies hearing loss currently limits our ability to intervene with small molecules. The present review focuses on the potential for the use of extracellular vesicles in otology. It examines a variety of inner ear diseases and hearing loss that may be treatable using exosomes (EXOs). The role of EXOs as carriers for the treatment of diseases related to the inner ear as well as EXOs as biomarkers for the recognition of diseases related to the ear is discussed.
引用
收藏
页数：10
相关论文
共 174 条
[1]   MicroRNAs and the resolution phase of inflammation in macrophages [J].
Alam, Muhammad M. ;
O'Neill, Luke A. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (09) :2482-2485
[2]   Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury [J].
Arslan, Fatih ;
Lai, Ruenn Chai ;
Smeets, Mirjam B. ;
Akeroyd, Lars ;
Choo, Andre ;
Aguor, Eissa N. E. ;
Timmers, Leo ;
van Rijen, Harold V. ;
Doevendans, Pieter A. ;
Pasterkamp, Gerard ;
Lim, Sai Kiang ;
de Kleijn, Dominique P. .
STEM CELL RESEARCH, 2013, 10 (03) :301-312
[3]  
Baghban N., 2023, Int. J. Stem Cell Res. Ther., V10
[4]   Fluorescent Metal Nano-Clusters as Next Generation Fluorescent Probes for Cell Imaging and Drug Delivery [J].
Bhattacharyya, Kankan ;
Mukherjee, Saptarshi .
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2018, 91 (03) :447-454
[5]   Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia [J].
Bian, Baishijiao ;
Zhao, Congjian ;
He, Xiangyu ;
Gong, Yu ;
Ren, Chunge ;
Ge, Lingling ;
Zeng, Yuxiao ;
Li, Qiyou ;
Chen, Min ;
Weng, Chuanhuang ;
He, Juncai ;
Fang, Yajie ;
Xu, Haiwei ;
Yin, Zheng Qin .
JOURNAL OF EXTRACELLULAR VESICLES, 2020, 9 (01)
[6]   Hearing Loss and Cognitive Impairment: Epidemiology, Common Pathophysiological Findings, and Treatment Considerations [J].
Bisogno, Antonella ;
Scarpa, Alfonso ;
Di Girolamo, Stefano ;
De Luca, Pietro ;
Cassandro, Claudia ;
Viola, Pasquale ;
Ricciardiello, Filippo ;
Greco, Antonio ;
Vincentiis, Marco De ;
Ralli, Massimo ;
Di Stadio, Arianna .
LIFE-BASEL, 2021, 11 (10)
[7]   The Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion [J].
Boker, Kai O. ;
Lemus-Diaz, Nicolas ;
Ferreira, Rafael Rinaldi ;
Schiller, Lara ;
Schneider, Stefan ;
Gruber, Jens .
MOLECULAR THERAPY, 2018, 26 (02) :634-647
[8]   Exosomes mediate sensory hair cell protection in the inner ear [J].
Breglio, Andrew M. ;
May, Lindsey A. ;
Barzik, Melanie ;
Welsh, Nora C. ;
Francis, Shimon P. ;
Costain, Tucker Q. ;
Wang, Lizhen ;
Anderson, D. Eric ;
Petralia, Ronald S. ;
Wang, Ya-Xian ;
Friedman, Thomas B. ;
Wood, Matthew J. A. ;
Cunningham, Lisa L. .
JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) :2657-2672
[9]   Extracellular heat shock proteins in cell signaling and immunity [J].
Calderwood, Stuart K. ;
Mambula, Salamatu S. ;
Gray, Phillip J., Jr. .
STRESS RESPONSES IN BIOLOGY AND MEDICINE: STRESS OF LIFE IN MOLECULES, CELLS, ORGANISMS, AND PSYCHOSOCIAL COMMUNITIES, 2007, 1113 :28-39
[10]   Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery? [J].
Castaneda, Rodrigo ;
Natarajan, Sathishkumar ;
Jeong, Seo Yule ;
Hong, Bin Na ;
Kang, Tong Ho .
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 231 :409-428
12345678910