Primary cutaneous EBV plus extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting

被引：0

作者：

Williams, Jessica F. ^{[1
]}

Lucas, Fabienne M. ^{[1
,2
]}

Carrasco, Ruben D. ^{[1
]}

Lovitch, Scott B. ^{[1
]}

Fisher, David C. ^{[3
]}

Kupper, Thomas S. ^{[4
]}

Sadigh, Sam ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Univ Washington, Dept Lab Med & Pathol, Seattle, WA USA

[3] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[4] Harvard Med Sch, Dana Farber Canc Inst, Dept Dermatol, Boston, MA USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2024年 / 51卷 / 10期

关键词：

EBV plus; extranodal NK/T-cell lymphoma; posttransplant lymphoproliferative disorder; primary cutaneous T-cell lymphoma; PTLD; EPSTEIN-BARR-VIRUS; NASAL-TYPE; LYMPHOPROLIFERATIVE DISORDERS; TRANSPLANT RECIPIENTS; PHASE-II; DISTINCT; OUTCOMES; PROTEIN;

D O I：

10.1111/cup.14677

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Posttransplantation primary cutaneous T-cell lymphomas (PT-CTCL) are a rare complication of sustained immunosuppression in the posttransplant setting. When present, PT-CTCLs are typically EBV- and exhibit features of mycosis fungoides/S & eacute;zary syndrome or CD30+ lymphoproliferative disorders. We present a case of a 75-year-old individual who developed skin lesions 30 years after liver transplantation. Pathologic evaluation of the skin biopsy revealed involvement by a clonal, EBV+ T-cell population of gamma/delta lineage with no evidence of systemic disease. Comprehensive genomic profiling was performed, confirming focal one-copy loss of 6q23.3, altogether consistent with the extremely rare and unusual diagnosis of primary cutaneous EBV+ extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting.

引用

页码：777 / 782

页数：6

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