Gut Microbiota Modulation in the Management of Chronic Obstructive Pulmonary Disease: A Literature Review

被引:1
作者
Patibandla, Srihita [1 ]
Bhatt, Nilay [2 ]
Lief, Sean [3 ]
Beauti, Samer M. [3 ]
Ansari, Ali Z. [4 ]
机构
[1] Trinity Hlth Grand Rapids, Dept Internal Med, Grand Rapids, MI 49503 USA
[2] Hosp Corp Amer HCA Houston Healthcare Clear Lake, Dept Internal Med, Webster, TX USA
[3] William Carey Univ, Coll Osteopath Med, Dept Internal Med, Hattiesburg, MS USA
[4] William Carey Univ, Coll Osteopath Med, Dept Pathol, Hattiesburg, MS 39401 USA
关键词
antibiotics; prebiotics; synbiotics; fiber; probiotics; gut dysbiosis; copd; fecal microbiota transplantation; gut microbiome; chronic obstructive pulmonary disease; DIETARY FIBER; LUNG AXIS; COPD; EXACERBATIONS; RISK; PREVENTION; THERAPY;
D O I
10.7759/cureus.66875
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic obstructive pulmonary disease (COPD) represents a significant global health burden, characterized by progressive airflow limitation and exacerbations that significantly impact patient morbidity and mortality. Recent research has investigated the interplay between the gut and the lungs, known as the gut- lung axis, highlighting the role of the gut microbiome in COPD pathogenesis. Dysbiosis, characterized by microbial imbalance, has implications for COPD, influencing disease progression and susceptibility to exacerbations. This comprehensive review integrates current scientific literature on gut microbiota modulation as a therapeutic avenue for COPD management. Through a thorough discussion of studies investigating probiotics, prebiotics, synbiotics, antibiotics, dietary fiber, and fecal microbiota transplantation, this review summarizes the influence of these interventions on COPD via the gut-lung axis through the modulation of systemic inflammation, mucosal immunity, and metabolic processes. The interventions highlighted here show potential in preventing COPD exacerbations, preserving lung function, and improving patient quality of life. By compiling the latest scientific evidence, this review provides a comprehensive framework for physicians and researchers to deduce the effectiveness of gut microbiome modulation as an adjunctive therapeutic strategy in COPD management.
引用
收藏
页数:18
相关论文
共 53 条
[1]  
Aimbire F, 2019, FASEB J, V33
[2]   Faecal microbial transfer and complex carbohydrates mediate protection against COPD [J].
Budden, Kurtis F. ;
Shukla, Shakti D. ;
Bowerman, Kate L. ;
Vaughan, Annalicia ;
Gellatly, Shaan L. ;
Wood, David L. A. ;
Lachner, Nancy ;
Idrees, Sobia ;
Rehman, Saima Firdous ;
Faiz, Alen ;
Patel, Vyoma K. ;
Donovan, Chantal ;
Alemao, Charlotte A. ;
Shen, Sj ;
Amorim, Nadia ;
Majumder, Rajib ;
Vanka, Kanth S. ;
Mason, Jazz ;
Haw, Tatt Jhong ;
Tillet, Bree ;
Fricker, Michael ;
Keely, Simon ;
Hansbro, Nicole ;
Belz, Gabrielle T. ;
Horvat, Jay ;
Ashhurst, Thomas ;
van Vreden, Caryn ;
McGuire, Helen ;
de St Groth, Barbara Fazekas ;
King, Nicholas J. C. ;
Crossett, Ben ;
Cordwell, Stuart J. ;
Bonaguro, Lorenzo ;
Schultze, Joachim L. ;
Hamilton-Williams, Emma E. ;
Mann, Elizabeth ;
Forster, Samuel C. ;
Cooper, Matthew A. ;
Segal, Leopoldo N. ;
Chotirmall, Sanjay H. ;
Collins, Peter ;
Bowman, Rayleen ;
Fong, Kwun M. ;
Yang, Ian A. ;
Wark, Peter A. B. ;
Dennis, Paul G. ;
Hugenholtz, Philip ;
Hansbro, Philip M. .
GUT, 2024, :751-769
[3]   Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice [J].
Budden, Kurtis F. ;
Gellatly, Shaan L. ;
Vaughan, Annalicia ;
Amorim, Nadia ;
Horvat, Jay C. ;
Hansbro, Nicole G. ;
Wood, David L. A. ;
Hugenholtz, Philip ;
Dennis, Paul G. ;
Wark, Peter A. B. ;
Hansbro, Philip M. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
[4]   Effects of long-term macrolide therapy at low doses in stable COPD [J].
Cao, Yueqin ;
Xuan, Shurui ;
Wu, Yunhui ;
Yao, Xin .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2019, 14 :1289-1298
[5]   Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells [J].
Carvalho, J. L. ;
Miranda, M. ;
Fialho, A. K. ;
Castro-Faria-Neto, H. ;
Anatriello, E. ;
Keller, C. ;
Aimbire, F. .
PLOS ONE, 2020, 15 (04)
[6]   Probiotics combined with Budesonide and Ipratropium bromide for chronic obstructive pulmonary disease: A retrospective analysis [J].
Chen, Chen ;
Wu, LingBo ;
Wang, LiJun ;
Tang, XinHeng .
MEDICINE, 2024, 103 (10) :E37309
[7]   Long-term macrolide treatment for the prevention of acute exacerbations in COPD: a systematic review and meta-analysis [J].
Cui, Yanan ;
Luo, Lijuan ;
Li, Chenbei ;
Chen, Ping ;
Chen, Yan .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2018, 13 :3813-3829
[8]   A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease [J].
Donath, Elie ;
Chaudhry, Abubakr ;
Hernandez-Aya, Leonel F. ;
Lit, Louis .
RESPIRATORY MEDICINE, 2013, 107 (09) :1385-1392
[9]  
Fialho AKCD, 2019, FASEB J, V33
[10]  
Hain J, 2021, Impact of dietary fiber and omega6/3 intake on COPD outcomes in U.S. adults