ZnO-Graphene Oxide Nanocomposite for Paclitaxel Delivery and Enhanced Toxicity in Breast Cancer Cells

被引：3

作者：

Madeo, Lorenzo Francesco ^{[1
,2
]}

Schirmer, Christine ^{[1
]}

Cirillo, Giuseppe ^{[3
]}

Asha, Ayah Nader ^{[4
]}

Ghunaim, Rasha ^{[4
]}

Froeschke, Samuel ^{[2
]}

Wolf, Daniel ^{[2
]}

Curcio, Manuela ^{[3
]}

Tucci, Paola ^{[3
]}

Iemma, Francesca ^{[3
]}

Buechner, Bernd ^{[2
,5
]}

Hampel, Silke ^{[2
]}

Mertig, Michael ^{[1
,6
]}

机构：

[1] Kurt Schwabe Inst Mess & Sensortech Meinsberg eV, D-04736 Waldheim, Germany

[2] Leibniz Inst Solid State & Mat Res Dresden, D-01069 Dresden, Germany

[3] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[4] Palestine Polytech Univ, Dept Appl Chem & Biol, POB 198, Hebron, Palestine

[5] Tech Univ Dresden, Inst Solid State & Mat Phys, D-01062 Dresden, Germany

[6] Tech Univ Dresden, Inst Phys Chem, D-01062 Dresden, Germany

来源：

MOLECULES | 2024年 / 29卷 / 16期

关键词：

zinc oxide nanoparticles; graphene oxide; nanocomposite; cancer therapy; Paclitaxel delivery; NANOPARTICLES; IMPACT; REDUCTION; GRAPHITE; RELEASE;

D O I：

10.3390/molecules29163770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A ZnO-Graphene oxide nanocomposite (Z-G) was prepared in order to exploit the biomedical features of each component in a single anticancer material. This was achieved by means of an environmentally friendly synthesis, taking place at a low temperature and without the involvement of toxic reagents. The product was physicochemically characterized. The ZnO-to-GO ratio was determined through thermogravimetric analysis, while scanning electron microscopy and transmission electron microscopy were used to provide insight into the morphology of the nanocomposite. Using energy-dispersive X-ray spectroscopy, it was possible to confirm that the graphene flakes were homogeneously coated with ZnO. The crystallite size of the ZnO nanoparticles in the new composite was determined using X-ray powder diffraction. The capacity of Z-G to enhance the toxicity of the anticancer drug Paclitaxel towards breast cancer cells was assessed via a cell viability study, showing the remarkable anticancer activity of the obtained system. Such results support the potential use of Z-G as an anticancer agent in combination with a common chemotherapeutic like Paclitaxel, leading to new chemotherapeutic formulations.

引用

页数：17