The effects of green coffee bean extract on blood pressure and heart rate: A systematic review and dose-response meta-analysis of randomized controlled trials

被引：1

作者：

Samavat, Simin ^{[1
]}

Ashtary-Larky, Damoon ^{[2
]}

Naeini, Fatemeh ^{[3
]}

Nazarian, Behzad ^{[4
]}

Kashkooli, Sara ^{[4
]}

Clark, Cain C. T. ^{[5
]}

Bagheri, Reza ^{[6
]}

Asbaghi, Omid ^{[7
]}

Babaali, Maryam ^{[8
]}

Goudarzi, Mohammad Ali ^{[9
]}

Zamanian, Ali ^{[10
]}

Emamat, Hadi ^{[11
]}

机构：

[1] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular Mol Nutr, Tehran, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran

[3] Univ Tehran Med Sci, Sch Nutr Sci, Dept Clin Nutr, Tehran, Iran

[4] Lorestan Univ Med Sci, Res Comm, Khorramabad, Iran

[5] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, England

[6] Univ Isfahan, Dept Exercise Physiol, Esfahan, Iran

[7] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran

[8] Islamic Azad Univ, Dept Sports Physiol, Damghan Branch, Damghan, Iran

[9] Islamic Azad Univ, Shahrekord Branch, Shahrekord, Iran

[10] Shahid Beheshti Univ Med Sci, Sci Nutr, Tehran, Iran

[11] Bushehr Univ Med Sci, Persian Gulf Biomed Sci Res Inst, Persian Gulf Trop Med Res Ctr, Bushehr, Iran

来源：

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2024年 / 18卷 / 09期

关键词：

Chlorogenic acid; Green coffee bean extract; Blood pressure; Heart rate; Meta-analysis; CELL-ADHESION MOLECULES; CHLOROGENIC ACID; GLYCEMIC CONTROL; DOUBLE-BLIND; ANTIOXIDANT; CONSUMPTION; RESISTANCE; INTERSALT; INDEXES; SAFETY;

D O I：

10.1016/j.dsx.2024.103120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: The existing literature on the effects of green coffee bean extract (GCBE) consumption on systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) is equivocal. This study aimed to summarize the effects of GCBE consumption on SBP, DBP and HR in adults. Methods: Data were pooled using a random-effects model and expressed as weighted mean difference (WMD) and 95 % confidence intervals (95 % CIs). Results: Out of 1624 records, 10 studies that enrolled 563 participants were included. GCBE consumption significantly decreased SBP (WMD: -2.95 mmHg; 95 % CI: -4.27 to -1.62; p < 0.001) and DBP (WMD: -2.15 mmHg; 95 % CI: -2.59 to -1.72; p < 0.001). However, there was no significant effect on HR (WMD: -1.20 bpm; CI: -2.93 to 0.51; p = 0.170). Subgroup analysis showed that GCBE consumption had a more significant effect on SBP and DBP in participants with high SBP and DBP and had no effect on blood pressure in females. Linear and non-linear dose-response analyses were conducted to find the optimum GCBE dosage and duration of intervention. However, no significant associations were observed for SBP, DBP, and HR in linear meta-regression and non-linear dose-response based on the dose and duration of the intervention. Conclusion: GCBE has the potential as a hypertension-reducing supplement in hypertensive patients. However, GCBE did not significantly change HR.

引用

页数：13

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