The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media

被引:0
作者
Kabus, Desmond [1 ,2 ]
Cloet, Marie [1 ]
Zemlin, Christian [3 ]
Bernus, Olivier [4 ]
Dierckx, Hans [1 ]
机构
[1] KU Leuven Campus Kortrijk KULAK, Dept Math, Kortrijk, Belgium
[2] Leiden Univ Med Ctr LUMC, Lab Expt Cardiol, Leiden, Netherlands
[3] Washington Univ, Dept Surg, Div Cardiothorac Surg, Sch Med, St Louis, MO USA
[4] Univ Bordeaux, Hop Xavier Arnozan, Ctr Rech Cardiothorac Bordeaux U1045, Inserm,IHU Liryc, Pessac, France
来源
PLOS ONE | 2024年 / 19卷 / 09期
关键词
SPIRAL BREAKUP; MODEL; SIMULATIONS; ALTERNANS; EQUATIONS; DYNAMICS; WAVES;
D O I
10.1371/journal.pone.0303674
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ithildin is an open-source library and framework for efficient parallelized simulations of excitable media, written in the C++ programming language. It uses parallelization on multiple CPU processors via the message passing interface (MPI). We demonstrate the library's versatility through a series of simulations in the context of the monodomain description of cardiac electrophysiology, including the S1S2 protocol, spiral break-up, and spiral waves in ventricular geometry. Our work demonstrates the power of Ithildin as a tool for studying complex wave patterns in cardiac tissue and its potential to inform future experimental and theoretical studies. We publish our full code with this paper in the name of open science.
引用
收藏
页数:26
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