Persteroid, a new steroid from the marine-derived fungus Penicillium sp. ZYX-Z-143

被引：0
作者：
Dai, Lu-Ting [1 ,2 ,3 ]
Yang, Li [1 ,2 ]
Wang, Zi-Peng [1 ,2 ]
Guo, Jiao-Cen [1 ,2 ]
Ma, Qing-Yun [1 ,2 ]
Xie, Qing-Yi [1 ,2 ]
Dai, Hao-Fu [1 ,2 ]
Yu, Zhi-Fang [3 ]
Zhao, You-Xing [1 ,2 ]
机构：
[1] Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China
[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou, Peoples R China
[3] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年
关键词：
Penicillium sp; steroid; PTP1B; anti-inflammatory; cytotoxicity; antibacterial activity;
D O I：
10.1080/14786419.2024.2394834
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new steroid named persteroid (1) and seven known compounds (2-8) were isolated from the marine-derived fungus Penicillium sp. ZYX-Z-143. The structure of 1 was determined by HRESIMS, NMR, and ECD calculations. Compound 1 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 value of 46.31 +/- 0.52 mu M. Moreover, compound 1 potently suppressed nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The cytotoxicity and antibacterial activity of all isolates were tested. [GRAPHICS]
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页数：8
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