Recent advances of nanozyme-enhanced lateral flow assay sensing in clinic diagnosis

被引:4
作者
Xiong, Haoxuan [2 ,3 ]
Hu, Peipei [4 ]
Zhang, Meimei [2 ,3 ]
Li, Yanping [2 ,3 ]
Ning, Zhenqiang [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Prov Clin Res Ctr Lab Med,Jiangxi Med Coll, Dept Clin Lab,Jiangxi Prov Key Lab Immunol & Infla, Nanchang 330006, Peoples R China
[2] Nanchang Univ, State Key Lab Food Sci & Resources, Nanchang 330047, Peoples R China
[3] Nanchang Univ, Jiangxi OAI Joint Res Inst, Nanchang 330047, Peoples R China
[4] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Hlth Management Ctr, Nanchang 330006, Peoples R China
基金
中国国家自然科学基金;
关键词
Nanozyme; Lateral flow assay; Point-of-care testing; Clinic diagnosis; Signal amplification; PEROXIDASE-LIKE ACTIVITY; ORGANIC FRAMEWORKS MOFS; SINGLE-ATOM NANOZYMES; NANOPARTICLES; NANOCATALYST; BIOSENSORS; DESIGNS; CANCER; FOOD;
D O I
10.1016/j.microc.2024.111602
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Nanozymes have recently garnered significant research attention in biosensing due to their unique properties, including high stability, tunable catalytic activity, and lower production costs than natural enzymes. Lateral flow assays (LFAs) are a representative point-of-care testing (POCT) technique known for their rapid and convenient detection of biological targets in complex matrices. By leveraging their exponential amplification capabilities, nanozymes have been extensively employed in LFA biosensors to enhance analytical sensitivity. This review expounds on recent advancements in nanozyme-based LFAs for clinical diagnosis. It briefly summarizes the working principle and categories of LFAs, classifies nanozymes, and discusses their diagnostic applications for various targets. Finally, the review explores the current challenges and future directions of nanozyme-based LFAs.
引用
收藏
页数:18
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