Exploring factors influencing choice of DNA double-strand break repair pathways

被引:5
作者
Otarbayev, Daniyar [1 ,2 ]
Myung, Kyungjae [1 ,2 ]
机构
[1] Inst Basic Sci, Ctr Genom Integr, Ulsan 44919, South Korea
[2] Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Ulsan 44919, South Korea
关键词
DNA double strand break repair; CRISPR-Cas9; End joining; Resection-mediated repair; HOMOLOGOUS RECOMBINATION; DAMAGE-RESPONSE; END RESECTION; POLYMERASE THETA; PROTEIN; COMPLEX; CAS9; ATM; LESIONS; KINASE;
D O I
10.1016/j.dnarep.2024.103696
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
DNA double-strand breaks (DSBs) represent one of the most severe threats to genomic integrity, demanding intricate repair mechanisms within eukaryotic cells. A diverse array of factors orchestrates the complex choreography of DSB signaling and repair, encompassing repair pathways, such as non-homologous end-joining, homologous recombination, and polymerase-theta-mediated end-joining. This review looks into the intricate decisionmaking processes guiding eukaryotic cells towards a particular repair pathway, particularly emphasizing the processing of two-ended DSBs. Furthermore, we elucidate the transformative role of Cas9, a site-specific endonuclease, in revolutionizing our comprehension of DNA DSB repair dynamics. Additionally, we explore the burgeoning potential of Cas9's remarkable ability to induce sequence-specific DSBs, offering a promising avenue for precise targeting of tumor cells. Through this comprehensive exploration, we unravel the intricate molecular mechanisms of cellular responses to DSBs, shedding light on both fundamental repair processes and cutting-edge therapeutic strategies.
引用
收藏
页数:10
相关论文
共 50 条
[41]   Playing the End Game: DNA Double-Strand Break Repair Pathway Choice [J].
Chapman, J. Ross ;
Taylor, Martin R. G. ;
Boulton, Simon J. .
MOLECULAR CELL, 2012, 47 (04) :497-510
[42]   Editorial: Protecting the code: DNA double-strand break repair pathway choice [J].
Singh, Jenny Kaur ;
Noordermeer, Sylvie M. ;
Jimenez-Sainz, Judit ;
Maranon, David G. ;
Altmeyer, Matthias .
FRONTIERS IN GENETICS, 2022, 13
[43]   RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair [J].
Blasiak, Janusz ;
Szczepanska, Joanna ;
Sobczuk, Anna ;
Fila, Michal ;
Pawlowska, Elzbieta .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
[44]   A Role for Small RNAs in DNA Double-Strand Break Repair [J].
Wei, Wei ;
Ba, Zhaoqing ;
Gao, Min ;
Wu, Yang ;
Ma, Yanting ;
Amiard, Simon ;
White, Charles I. ;
Danielsen, Jannie Michaela Rendtlew ;
Yang, Yun-Gui ;
Qi, Yijun .
CELL, 2012, 149 (01) :101-112
[45]   DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome [J].
Blundred, Rachel M. ;
Stewart, Grant S. .
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2011, 7 (02) :169-185
[46]   Role of deubiquitinating enzymes in DNA double-strand break repair [J].
Li, Yunhui ;
Yuan, Jian .
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B, 2021, 22 (01) :63-72
[47]   Reconsidering pathway choice: a sequential model of mammalian DNA double-strand break pathway decisions [J].
Paull, Tanya T. .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2021, 71 :55-62
[48]   Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1 [J].
Zhang, Fan ;
Gong, Zihua .
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B, 2021, 22 (01) :38-46
[49]   A quantitative model of the major pathways for radiation-induced DNA double-strand break repair [J].
Belov, Oleg V. ;
Krasavin, Eugene A. ;
Lyashko, Marina S. ;
Batmunkh, Munkhbaatar ;
Sweilam, Nasser H. .
JOURNAL OF THEORETICAL BIOLOGY, 2015, 366 :115-130
[50]   Pathways for Double-strand Break Repair in Genetically Unstable Z-DNA-forming Sequences [J].
Kha, Diem T. ;
Wang, Guliang ;
Natrajan, Nithya ;
Harrison, Lynn ;
Vasquez, Karen M. .
JOURNAL OF MOLECULAR BIOLOGY, 2010, 398 (04) :471-480