Synthesis of α-hydroxyketones via palladium-catalyzed arylation of arylglyoxals

被引：0

作者：

Li, Si-Yu ^{[1
]}

Ai, Zhao-Pin ^{[1
]}

Guo, Qi-Xiang ^{[1
]}

Wen, Wei ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China

来源：

TETRAHEDRON | 2024年 / 166卷

关键词：

alpha-hydroxyketones; Palladium catalysis; Arylation; Arylglyoxals; FRIEDEL-CRAFTS REACTION; ARYL BORONIC ACIDS; ONE-POT SYNTHESIS; ARYLBORONIC ACIDS; ENANTIOSELECTIVE SYNTHESIS; BENZYL ALCOHOLS; KETONES; HYDROXYLATION; 1,2-ADDITION; DIKETONES;

D O I：

10.1016/j.tet.2024.134214

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed arylation reaction of arylglyoxals with arylboronic acids has been achieved. The reaction produces various acyclic alpha-hydroxyketones in high yields under mild conditions. Of merits mention, the rigorous exclusion of air and moisture is not required in these transformations, offering a straightforward and practical approach for the synthesis of alpha-hydroxyketones.

引用

页数：7

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