Immunogenicity and protective efficacy of the HC009 mRNA vaccine against SARS-CoV-2

被引：2

作者：

Liu, Juan ^{[1
]}

Han, Huafeng ^{[1
]}

Yang, Binbin ^{[1
]}

Zhang, Naifang ^{[1
]}

Li, Jing ^{[1
]}

Chen, Xicheng ^{[1
]}

Wu, Jie ^{[1
]}

Zhao, Yingying ^{[1
]}

Yang, Yongsheng ^{[1
]}

机构：

[1] Zhejiang Haichang Biotech Co Ltd, Nucl Acid Med Innovat Ctr, Hangzhou, Zhejiang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

mRNA vaccine; SARS-CoV-2; immunogenicity; prime-boost; humoral immunity; immune protection; SPIKE;

D O I：

10.3389/fimmu.2024.1416375

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With the rapid global spread of COVID-19 and the continuous emergence of variants, there is an urgent need to develop safe and effective vaccines. Here, we developed a novel mRNA vaccine, HC009, based on new formulation by the QTsome delivery platform. Immunogenicity results showed that the prime-boost immunization strategy with HC009 was able to induce robust and durable humoral immunity, as well as Th1-biased cellular responses in rodents or non-human primates (NHPs). After further challenge with live SARS-CoV-2 virus, HC009 provided adequate protection against virus infection in hACE2 transgenic mice. Therefore, HC009 could provide significant immune protection against SARS-CoV-2.

引用

页数：14

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