Polypharmacy and Elevated Risk of Severe Adverse Events in Older Adults Based on the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database

被引:3
|
作者
Kim, Grace Juyun [1 ]
Lee, Ji Sung [2 ]
Jang, Sujung [3 ]
Lee, Seonghui [4 ]
Jeon, Seongwoo [5 ]
Lee, Suehyun [6 ]
Kim, Ju Han [7 ]
Lee, Kye Hwa [8 ,9 ]
机构
[1] Asan Med Ctr, Asan Inst Life Sci, Big Data Res Ctr, Seoul, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Inst Life Sci,Clin Res Ctr, Seoul, South Korea
[3] Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr, Dept Biomed Engn,Coll Med, Seoul, South Korea
[4] EVIDNET, Healthcare Contents, Seoul, South Korea
[5] Chungbuk Natl Univ, Coll Med, Cheongju, South Korea
[6] Gachon Univ, Dept Comp Engn, Seongnam, South Korea
[7] Seoul Natl Univ, Div Biomed Informat, Seoul, South Korea
[8] Asan Med Ctr, Dept Informat Med, Seoul, South Korea
[9] Yonsei Univ, Coll Med, Dept Biomed Informat, Seoul, South Korea
关键词
Drug-Related Side Effects and Adverse Reactions; Spontaneous Reports; Polypharmacy; Elderly;
D O I
10.3346/jkms.2024.39.e205
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Older adults are at a higher risk of severe adverse drug events (ADEs) because of multimorbidity, polypharmacy, and lower physiological function. This study aimed to determine whether polypharmacy, defined as the use of >= 5 active drug ingredients, was associated with severe ADEs in this population. Methods: We used ADE reports from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database, a national spontaneous ADE report system, from 2012 to 2021 to examine and compare the strength of association between polypharmacy and severe ADEs in older adults (>= 65 years) and younger adults (20-64 years) using disproportionality analysis. Results: We found a significant association between severe ADEs of cardiac and renal/ urinary Medical Dictionary for Regulatory Activities System Organ Classes (MedDRA SOC) with polypharmacy in older adults. Regarding individual-level ADEs included in these MedDRA SOCs, acute cardiac arrest and renal failure were more significantly associated with polypharmacy in older adults compared with younger adults. Conclusion: The addition of new drugs to the regimens of older adults warrants close monitoring of renal and cardiac symptoms.
引用
收藏
页数:18
相关论文
共 50 条
  • [1] The Current Status of Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database in the Republic of Korea
    Oh, S.
    Kim, B.
    Jang, B.
    Kim, D.
    Kim, H.
    Shin, S.
    Chung, S. Y.
    DRUG SAFETY, 2019, 42 (10) : 1207 - 1207
  • [2] Signal detection for adverse events of dapagliflozin using the Korea adverse event reporting system database
    Park, Suvin
    Lee, Huieon
    Kim, Hee-Jin
    Jeong, Na-Young
    Lim, Eunsun
    Choi, Nam-Kyong
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2022, 31 : 597 - 597
  • [3] Signal Detection of Adverse Drug Reaction of Amoxicillin Using the Korea Adverse Event Reporting System Database
    Soukavong, Mick
    Kim, Jungmee
    Park, Kyounghoon
    Yang, Bo Ram
    Lee, Joongyub
    Jin, Xue-Mei
    Park, Byung-Joo
    JOURNAL OF KOREAN MEDICAL SCIENCE, 2016, 31 (09) : 1355 - 1361
  • [4] COMPARISON OF ADVERSE DRUG REACTIONS BETWEEN OLDER AND YOUNGER PATIENTS IN KOREA: USING ADVERSE EVENT REPORTING SYSTEM DATABASE FOR 2013-2015
    Je, S.
    Kim, N. H.
    Song, S. M.
    Lim, S. J.
    Suh, D.
    VALUE IN HEALTH, 2017, 20 (05) : A37 - A37
  • [5] Data mining for detecting signals of adverse drug reaction of doxycycline using the Korea adverse event reporting system database
    Heo, Jae Young
    Cho, Moon Kyun
    Kim, Sooyoung
    JOURNAL OF DERMATOLOGICAL TREATMENT, 2022, 33 (04) : 2192 - 2197
  • [6] Reducing the Risk of Adverse Drug Events in Older Adults
    Pretorius, Richard W.
    Gataric, Gordana
    Swedlund, Steven K.
    Miller, John R.
    AMERICAN FAMILY PHYSICIAN, 2013, 87 (05) : 329 - 334
  • [7] Comparative analysis of adverse drug reactions associated with new antiseizure medications from the Korea Adverse Event Reporting System database
    Kim, Hyun Kyung
    Jang, Kyung Sik
    Kim, Dong Wook
    EPILEPSY & BEHAVIOR, 2024, 154
  • [8] Fluoxetine and Risk of Bleeding in Patients Aged 60 Years and Older Using the Korea Adverse Event Reporting System Database A Case/Noncase Study
    Kim, Seonji
    Ko, Young-Jin
    Park, Kyounghoon
    Yang, Bo Ram
    Kim, Mi-sook
    Park, Byung-Joo
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2019, 39 (04) : 362 - 366
  • [9] Signal detection of zoster vaccine adverse event in elderly using Korea adverse event reporting system database (KAERS)
    Lim, Eunsun
    Jeong, Na-Young
    Won, HeHyun
    Choi, HyunYoung
    Jung, Sun-Young
    Shin, Ju-Young
    Choi, Nam-Kyong
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2021, 30 : 339 - 340
  • [10] Signal Detection of Adverse Events Following Pneumococcal Vaccines from the Korea Adverse Event Reporting System Database, 2005-2016
    Kim, Kwan Soo
    Oh, In-Sun
    Kim, Hyun Jeong
    Song, Inmyung
    Park, Min Soo
    Shin, Ju-Young
    YONSEI MEDICAL JOURNAL, 2020, 61 (03) : 243 - 250