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Polypharmacy and Elevated Risk of Severe Adverse Events in Older Adults Based on the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database
被引:3
|作者:
Kim, Grace Juyun
[1
]
Lee, Ji Sung
[2
]
Jang, Sujung
[3
]
Lee, Seonghui
[4
]
Jeon, Seongwoo
[5
]
Lee, Suehyun
[6
]
Kim, Ju Han
[7
]
Lee, Kye Hwa
[8
,9
]
机构:
[1] Asan Med Ctr, Asan Inst Life Sci, Big Data Res Ctr, Seoul, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Inst Life Sci,Clin Res Ctr, Seoul, South Korea
[3] Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr, Dept Biomed Engn,Coll Med, Seoul, South Korea
[4] EVIDNET, Healthcare Contents, Seoul, South Korea
[5] Chungbuk Natl Univ, Coll Med, Cheongju, South Korea
[6] Gachon Univ, Dept Comp Engn, Seongnam, South Korea
[7] Seoul Natl Univ, Div Biomed Informat, Seoul, South Korea
[8] Asan Med Ctr, Dept Informat Med, Seoul, South Korea
[9] Yonsei Univ, Coll Med, Dept Biomed Informat, Seoul, South Korea
关键词:
Drug-Related Side Effects and Adverse Reactions;
Spontaneous Reports;
Polypharmacy;
Elderly;
D O I:
10.3346/jkms.2024.39.e205
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background: Older adults are at a higher risk of severe adverse drug events (ADEs) because of multimorbidity, polypharmacy, and lower physiological function. This study aimed to determine whether polypharmacy, defined as the use of >= 5 active drug ingredients, was associated with severe ADEs in this population. Methods: We used ADE reports from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database, a national spontaneous ADE report system, from 2012 to 2021 to examine and compare the strength of association between polypharmacy and severe ADEs in older adults (>= 65 years) and younger adults (20-64 years) using disproportionality analysis. Results: We found a significant association between severe ADEs of cardiac and renal/ urinary Medical Dictionary for Regulatory Activities System Organ Classes (MedDRA SOC) with polypharmacy in older adults. Regarding individual-level ADEs included in these MedDRA SOCs, acute cardiac arrest and renal failure were more significantly associated with polypharmacy in older adults compared with younger adults. Conclusion: The addition of new drugs to the regimens of older adults warrants close monitoring of renal and cardiac symptoms.
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