Potential prognostic value of rheumatoid factor in anti-aquaporin 4-immunoglobin G-positive neuromyelitis optica spectrum disorders

被引：1

作者：

Lee, Hye Lim ^{[1
]}

Seok, Jin Myoung ^{[2
]}

Hwang, Soon-Young ^{[3
]}

Cho, Eun Bin ^{[4
]}

Kim, Hojin ^{[5
]}

Shin, Ha Young ^{[6
]}

Kim, Byung-Jo ^{[7
]}

Baek, Seol-Hee ^{[7
]}

Seok, Hung Youl ^{[8
]}

Kang, Sa-Yoon ^{[9
]}

Kwon, Ohyun ^{[10
]}

Lim, Young-Min ^{[11
]}

Lee, Sang-Soo ^{[12
]}

Oh, Jeeyoung ^{[13
]}

Huh, So-Young ^{[14
]}

Kim, Jong Kuk ^{[15
]}

Yoon, Byeol-A ^{[15
]}

Sohn, Eun-Hee ^{[16
]}

Kim, Sooyoung ^{[16
]}

Cho, Joong-Yang ^{[17
]}

Min, Ju-Hong ^{[18
,19
,20
]}

Kim, Byoung Joon ^{[18
,19
]}

机构：

[1] Korea Univ, Korea Univ Guro Hosp, Dept Neurol, Coll Med, Seoul, South Korea

[2] Soonchunhyang Univ, Cheonan Hosp, Dept Neurol, Cheonan, South Korea

[3] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea

[4] Gyeongsang Natl Univ, Changwon Gyeongsang Inst Hlth Sci, Sch Med, Dept Neurol, Chang Won, South Korea

[5] Res Inst & Hosp Natl Canc Ctr, Dept Neurol, Goyang, South Korea

[6] Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea

[7] Korea Univ, Korea Coll Med, Dept Neurol, Anam Hosp, Seoul, South Korea

[8] Keimyung Univ, Sch Med, Dept Neurol, Daegu, South Korea

[9] Jeju Natl Univ, Coll Med, Dept Neurol, Cheju, South Korea

[10] Eulji Univ, Dept Neurol, Coll Med, Daejeon, South Korea

[11] Univ Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, Seoul, South Korea

[12] Chungbuk Natl Univ, Coll Med, Dept Neurol, Cheongju, South Korea

[13] Konkuk Univ, Coll Med, Dept Neurol, Seoul, South Korea

[14] Kosin Univ, Coll Med, Dept Neurol, Busan, South Korea

[15] Dong A Univ Hosp, Dept Neurol, Busan, South Korea

[16] Chungnam Natl Univ, Coll Med, Dept Neurol, Daejeon, South Korea

[17] Inje Univ, Coll Med, Dept Neurol, Ilsan, South Korea

[18] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Neurol, Seoul, South Korea

[19] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea

[20] Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2024年 / 466卷

基金：

新加坡国家研究基金会;

关键词：

Neuromyelitis optica spectrum disorder; Autoantibodies; Rheumatoid factor; Aquaporin-4; Disability; Multiple sclerosis; CLINICAL CHARACTERISTICS; MULTIPLE-SCLEROSIS; DISEASE-ACTIVITY; AUTOANTIBODIES; ANTIBODIES; DISABILITY; FREQUENCY;

D O I：

10.1016/j.jns.2024.123215

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Neuromyelitis optica spectrum disorder (NMOSD) is the central nervous system demyelinating disease differentiated from multiple sclerosis by the presence of anti-aquaporin 4-antibody (AQP4-ab), which is sometimes accompanied by non-organ-specific autoantibodies. Methods: We prospectively collected clinical information and profiles of non-organ-specific autoantibodies such as fluorescent antinuclear (FANA), anti-Sjo<spacing diaeresis>gren's syndrome A (SSA)/Ro, anti-SS B (SSB)/La, anti-neutrophil cytoplasmatic (ANCA), lupus anticoagulant (LA), anti-cardiolipin (ACA), anti-double-stranded DNA (dsDNA), rheumatoid factor (RF), anti-thyroperoxidase, and anti-thyroglobulin antibodies in patients with NMOSD. Clinical characteristics and laboratory findings of patients with NMOSD with or without autoantibodies were analyzed. Cox proportional hazard models were used to identify independent risk factors predicting high disability in patients with NMOSD. Results: A total of 158 patients with NMOSD (Female: Male = 146:12; age, 36.11 +/- 14.7) were included. FANA was observed most frequently (33.3 %), followed by anti-SSA (28.6 %), anti-SSB (10.0 %), RF (8.5 %), antidsDNA (7.0 %), LA (4.7 %), ACA (4.8 %), and ANCA (2.4 %). High disability (Expanded Disability Status Scale (EDSS) score >= 6) was observed more frequently in patients with RF (45.5 %) than in those without RF (14.5 %) (p p = 0.02). RF was a significant predictive factor for the high disability (hazard ratio [HR], 3.763; 95 % confidence interval [CI], 1.086-13.038; p = 0.037), age at onset (HR, 1.093; 95 % CI, 1.05-1.14; p <= 0.001), and annual relapse rate (ARR) (HR, 4.212; 95 % CI, 1.867-9.503; p = 0.001). Conclusion: Organ-specific and non-organ-specific autoantibodies are frequently observed in Korean patients with AQP4-ab-positive NMOSD. RF may be an independent predictor of high disability, along with age at onset and ARR.

引用

页数：7

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