Production and characterization of encapsulated Thymoquinone loaded bacterial cellulose/chitosan composite nano film and investigation of its in vitro antibacterial activity

In this study, nanostructured thin fi lms were produced from thymoquinone (TQ)-loaded composites encapsulated with different ratios of bacterial nanocellulose (BNC) to chitosan (CS). The study aimed to investigate their characterization, antibacterial effects, and potential as drug fi lm coating materials. Chemical features and morphological characteristics were determined, and release tests and antibacterial assays were conducted on the thin fi lm layers. As a result, BNC/CS-thymoquinone composite fi lms obtained at different ratios were found to exhibit the highest antibacterial effect, particularly fi lms with a 70% BNC/CS to 30% thymoquinone ratio, against Salmonella typhimurium bacteria.