Self-reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort

被引:2
作者
Miller, Alyssa A. [1 ,2 ]
Sharp, Emily S. [1 ,3 ]
Wang, Selena [4 ,5 ]
Zhao, Yize [4 ]
Mecca, Adam P. [1 ,2 ]
van Dyck, Christopher H. [1 ,2 ,3 ,6 ]
O'Dell, Ryan S. [1 ,2 ]
机构
[1] Yale Univ, Sch Med, Alzheimers Dis Res Unit, One Church St,8th Floor, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[4] Yale Univ, Sch Publ Hlth, Dept Biostat, New Haven, CT 06510 USA
[5] Indiana Univ Sch Med, Dept Biostat & Hlth Data Sci, Indianapolis, IN USA
[6] Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06510 USA
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
cognition; conversion; hearing loss; memory; neuropsychological testing; VERBAL LEARNING TEST; ALZHEIMERS-DISEASE; OLDER-ADULTS; COMPOSITE SCORE; DEMENTIA; MEMORY; IMPAIRMENT; HEALTH; SCALE;
D O I
10.1002/alz.14252
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
INTRODUCTIONHearing loss is identified as one of the largest modifiable risk factors for cognitive impairment and dementia. Studies evaluating this relationship have yielded mixed results.METHODSWe investigated the longitudinal relationship between self-reported hearing loss and cognitive/functional performance in 695 cognitively normal (CN) and 941 participants with mild cognitive impairment (MCI) enrolled in the Alzheimer's Disease Neuroimaging Initiative.RESULTSWithin CN participants with hearing loss, there was a significantly greater rate of cognitive decline per modified preclinical Alzheimer's cognitive composite. Within both CN and MCI participants with hearing loss, there was a significantly greater rate of functional decline per the functional activities questionnaire (FAQ). In CN and MCI participants, hearing loss did not significantly contribute to the risk of progression to a more impaired diagnosis.DISCUSSIONThese results confirm previous studies demonstrating a significant longitudinal association between self-reported hearing loss and cognition/function but do not demonstrate an increased risk of conversion to a more impaired diagnosis.CLINICAL TRIAL REGISTRATION INFORMATIONNCT00106899 (ADNI: Alzheimer's Disease Neuroimaging Initiative, clinicaltrials.gov), NCT01078636 (ADNI-GO: Alzheimer's Disease Neuroimaging Initiative Grand Opportunity, clinicaltrials.gov), NCT01231971 (ADNI2: Alzheimer's Disease Neuroimaging Initiative 2, clinicaltrials.gov), NCT02854033 (ADNI3: Alzheimer's Disease Neuroimaging Initiative 3, clinicaltrials.gov).Highlights Hearing loss is a potential modifiable risk factor for dementia. We assessed the effect of self-reported hearing loss on cognition and function in the ADNI cohort. Hearing loss contributes to significantly faster cognitive and functional decline. Hearing loss was not associated with conversion to a more impaired diagnosis.
引用
收藏
页码:7847 / 7858
页数:12
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