xenograft;
genetically modified pig;
right ventricle to pulmonary artery conduit;
congenital;
pediatric;
HOMOGRAFTS;
D O I:
10.1097/MAT.0000000000002213
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
The last 40 years have shown dramatic improvement in outcomes for neonatal cardiac surgery for a spectrum of congenital heart disease diagnoses. With more patients surviving into adulthood, the long-term impact of initial management strategies of these patients has come into focus. This is particularly true for patients with pediatric heart valve disease. Many patients born with right ventricular to pulmonary artery (RVPA) discontinuity require placement of a valved conduit in the neonatal period. Valved conduit options are limited in this patient population due to patient size and inability to respond to somatic growth. Genetically engineered porcine (GEP) donors may offer a xenograft conduit alternative that can grow with the patient. We have developed a model utilizing GEP donor RVPA conduits placed in infantile nonhuman primate (NHP) recipients. Our recipient is maintained on single-drug immunosuppression and demonstrates no evidence of pulmonary valve insufficiency or stenosis during short-term follow-up. Further studies and long-term outcomes are necessary to determine the utility of this technology in human application.
机构:
Ohio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USAOhio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA
Bowden, S.
Winter, R. L.
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机构:
Auburn Univ, Coll Vet Med, Dept Clin Sci, 1220 Wire Rd, Auburn, AL 36832 USAOhio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA
Winter, R. L.
Hostnik, E. T.
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机构:
Ohio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USAOhio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA
Hostnik, E. T.
Habing, A.
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机构:
Ohio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USAOhio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA
Habing, A.
Green, E.
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机构:
Ohio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USAOhio State Univ, Coll Vet Med, Dept Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiovasc Surg, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiovasc Surg, Beijing, Peoples R China
Wang, Zhangwei
Ma, Kai
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiovasc Surg, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiovasc Surg, Beijing, Peoples R China
Ma, Kai
Li, Shoujun
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiovasc Surg, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiovasc Surg, Beijing, Peoples R China