The impact of systemic and topical antimicrobial therapy combined with non-surgical periodontal therapy: A meta-analysis

被引:1
作者
Sun, Guangping [1 ]
机构
[1] Jinan Third Peoples Hosp, Dept Stomatol, Jinan, Shandong, Peoples R China
来源
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE | 2025年 / 34卷 / 05期
关键词
periodontal therapy; antimicrobials; CAL; PPD; GENERALIZED AGGRESSIVE PERIODONTITIS; GLYCEMIC CONTROL; IMMUNOLOGICAL PARAMETERS; ADJUNCTIVE THERAPY; DIABETES-MELLITUS; METRONIDAZOLE; AMOXICILLIN; DOXYCYCLINE; AMOXICILLIN/METRONIDAZOLE; EFFICACY;
D O I
10.17219/acem/188258
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background. Combining antibiotics with non-surgical periodontal therapy has a beneficial impact in case of infection while its role for dental-related outcomes is still unclear. Objectives. The current study's main objective was to evaluate the impact of adding adjuvant systemic and topical antimicrobial therapy to non-surgical periodontal therapy. Materials and methods. A systematic literature search was accomplished and 1,093 study participants with periodontal diseases were recruited to the current study; 541 of them were treated with adjuvant systemic or topical antimicrobial agents and 552 with non-surgical interventions. The inclusion criteria of the current study took into account only randomized clinical trials. Results. Adding systemic antibiotics to non-surgical intervention resulted in a significant enhancement regarding probing pocket depth reduction (PPD). Metronidazole/amoxicillin showed a significant impact on PPD and the clinical attachment level (CAL), while doxycycline showed no significant impact regarding CAL. Using topical antimicrobial agents showed a significant beneficial role in reducing PPD regarding doxycycline, while non-significant effects were seen with metronidazole. Conclusions. Adding adjuvant systemic and topical antimicrobial agents to non-surgical periodontal therapy showed a beneficial impact regarding PPD and CAL (metronidazole/amoxicillin and doxycycline). In addition, using doxycycline as a topical agent showed a beneficial impact on the reduction of PPD.
引用
收藏
页码:681 / 692
页数:12
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