Emerging roles of hydrogen sulfide in colorectal cancer

被引：1

作者：

Jiang, Zhi-Liang ^{[1
,2
]}

Liu, Yi ^{[1
,3
]}

Zhang, Chuan-Hao ^{[1
,2
]}

Chu, Ti ^{[1
]}

Yang, Yi-Lun ^{[1
,3
]}

Zhu, Yi-Wen ^{[1
,2
]}

Wang, Yan ^{[1
]}

Liu, Ya-Fang ^{[1
,3
]}

Zhang, Yan-Xia ^{[1
]}

Feng, Zhi-Fen ^{[4
]}

Ji, Xin-Ying ^{[1
,5
,6
]}

Wu, Dong-Dong ^{[1
,3
,7
]}

机构：

[1] Henan Univ, Sch Basic Med Sci, Sch Stomatol, Henan Int Joint Lab Nucl Prot Regulat, Kaifeng 475004, Henan, Peoples R China

[2] Henan Univ, Sch Clin Med, Kaifeng 475004, Henan, Peoples R China

[3] Henan Univ, Sch Stomatol, Kaifeng Key Lab Periodontal Tissue Engn, Kaifeng 475000, Henan, Peoples R China

[4] Henan Univ, Sch Nursing & Hlth, Kaifeng 475004, Henan, Peoples R China

[5] Huaxian Cty Peoples Hosp, Dept Med, Anyang 456400, Henan, Peoples R China

[6] Shu Qing Med Coll Zhengzhou, Fac Basic Med Subjects, Ctr Mol Med, Zhengzhou 450064, Henan, Peoples R China

[7] Henan Univ, Huaihe Hosp, Dept Stomatol, Kaifeng 475000, Henan, Peoples R China

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2024年 / 403卷

基金：

中国国家自然科学基金;

关键词：

Hydrogen sulfide; Endogenous gas transmitter; Colorectal cancer; Signal transduction; CYSTATHIONINE-BETA-SYNTHASE; SULFATE-REDUCING BACTERIA; CELL-CYCLE ARREST; DIALLYL TRISULFIDE; 3-MERCAPTOPYRUVATE SULFURTRANSFERASE; CARCINOMA-CELLS; DOWN-REGULATION; BLADDER-CANCER; ALLYL SULFIDES; UP-REGULATION;

D O I：

10.1016/j.cbi.2024.111226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen sulfide (H2S), an endogenous gasotransmitter, plays a key role in several critical physiological and pathological processes in vivo, including vasodilation, anti-infection, anti-tumor, anti-inflammation, and angiogenesis. In colorectal cancer (CRC), aberrant overexpression of H2S-producing enzymes has been observed. Due to the important role of H2S in the proliferation, growth, and death of cancer cells, H2S can serve as a potential target for cancer therapy. In this review, we thoroughly analyzed the underlying mechanism of action of H2S in CRC from the following aspects: the synthesis and catabolism of H2S in CRC cells and its effect on cell signal transduction pathways; the inhibition effects of exogenous H2S donors with different concentrations on the growth of CRC cells and the underlying mechanism of H2S in garlic and other natural products. Furthermore, we elucidate the expression characteristics of H2S in CRC and construct a comprehensive H2S-related signaling pathway network, which has important basic and practical significance for promoting the clinical research of H2S-related drugs.a

引用

页数：10

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