Long-term ambient ozone exposure and childhood asthma, rhinitis, eczema, and conjunctivitis: A multi-city study in China

被引:3
|
作者
Gui, Zhao-Huan [1 ]
Guo, Zhan-Yu [2 ]
Zhou, Yang [3 ]
Dharmage, Shyamali [4 ]
Morawska, Lidia [5 ]
Heinrich, Joachim [4 ,6 ]
Cheng, Zhang-Kai [7 ]
Gan, Hui [7 ]
Lin, Zhi-Wei [7 ]
Zhang, Dong-Ying [7 ]
Huang, Jing-Wen [1 ]
Lin, Li-Zi [1 ]
Liu, Ru-Qing [1 ]
Chen, Wen [2 ]
Sun, Bao-qing [7 ]
Dong, Guang-Hui [1 ]
机构
[1] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth,Minist Educ,Joint Int, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China
[2] Sun Yat Sen Univ, Sch Publ Hlth, Dept Toxicol, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China
[3] Minist Ecol & Environm, South China Inst Environm Sci, State Environm Protect Key Lab Environm Pollut Hlt, Guangzhou, Peoples R China
[4] Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Australia
[5] Queensland Univ Technol, Int Lab Air Qual & Hlth, Brisbane, Australia
[6] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Munich, Germany
[7] Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, Affiliated Hosp 1 ,Dept Allergy & Clin Immunol,Sta, Guangzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Environmental health impacts; Ozone pollution; Pediatric respiratory diseases; Asthma; Allergies; AIR-POLLUTION; RESPIRATORY HEALTH; ALLERGIC RHINITIS; CHILDREN; POLLUTANTS; INFLAMMATION; PREVALENCE; HYPERRESPONSIVENESS; ASSOCIATIONS; ADULTS;
D O I
10.1016/j.jhazmat.2024.135577
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Evidence on the link of long-term exposure to ozone (O-3) with childhood asthma, rhinitis, conjunctivitis and eczema is inconclusive. We did a population-based cross-sectional survey, including 177,888 children from 173 primary and middle schools in 14 Chinese cities. A satellite-based spatiotemporal model was employed to assess four-year average O-3 exposure at both residential and school locations. Information on asthma, allergic rhinitis, eczema and conjunctivitis was collected by a standard questionnaire developed by the American Thoracic Society. We used generalized non-linear and linear mixed models to test the associations. We observed linear exposure-response associations between O-3 and all outcomes. The odds ratios of doctor-diagnosed asthma, rhinitis, eczema, and conjunctivitis associated with per interquartile increment in home-school O-3 concentration were 1.31 (95 % confidence interval [CI]: 1.28, 1.34), 1.25 (95 %CI: 1.23, 1.28), 1.19 (95 %CI: 1.16, 1.21), and 1.28 (95 %CI: 1.21, 1.34), respectively. Similar associations were observed for asthma-related outcomes including current asthma, wheeze, current wheeze, persistent phlegm, and persistent cough. Moreover, stronger associations were observed among children who were aged > 12 years, physically inactive, and exposed to higher temperature. In conclusion, long-term O-3 exposure was associated with higher risks of asthma, allergic rhinitis, conjunctivitis and eczema in children.
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页数:10
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