Impact of prenatal and postnatal maternal IBD status on offspring's risk of IBD: a population-based cohort study

被引:3
作者
Bonfils, Linea [1 ]
Poulsen, Gry [1 ]
Agrawal, Manasi [1 ,2 ]
Julsgaard, Mette [1 ,3 ]
Torres, Joana [2 ,4 ,5 ]
Jess, Tine [1 ,6 ]
Allin, Kristine Hojgaard [1 ,6 ]
机构
[1] Aalborg Univ, Dept Clin Med, DK-2450 Copenhagen, Denmark
[2] Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY USA
[3] Aarhus Univ Hosp, Dept Gastroenterol & Hepatol, Aarhus, Denmark
[4] Hosp Beatriz Angelo, Div Gastroenterol, Loures, Portugal
[5] Hosp Da Luz, Div Gastroenterol, Lisbon, Portugal
[6] Aalborg Univ Hosp, Dept Gastroenterol & Hepatol, Aalborg, Denmark
来源
基金
新加坡国家研究基金会;
关键词
EPIDEMIOLOGY; ULCERATIVE COLITIS; CROHN'S DISEASE; INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; FAMILIAL AGGREGATION; GENETIC ARCHITECTURE; ASSOCIATION; SUSCEPTIBILITY; PREVALENCE; MICROBIOTA; HEALTH; LOCI;
D O I
10.1136/gutjnl-2024-332885
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective In utero exposure to maternal inflammation may impact immune system development and subsequent risk of disease. We investigated whether a maternal diagnosis of IBD before childbirth is linked to a higher risk of IBD in offspring compared with a diagnosis after childbirth. Further, we analysed paternal IBD status for comparison. Design Using Danish health registers, we identified all individuals born in Denmark between 1997 and 2022 and their legal parents, as well as their IBD status. Cox proportional hazards regression analyses adjusted for calendar period and mode of delivery were used to estimate offspring IBD risk by maternal and paternal IBD status before and after childbirth. Results Of 1 290 358 children, 10 041 (0.8%) had mothers with IBD diagnosis before childbirth and 9985 (0.8%) had mothers with IBD diagnosis after childbirth. Over 18 370 420 person-years, 3537 individuals were diagnosed with IBD. Offspring of mothers with IBD before childbirth had an adjusted HR of IBD of 6.27 (95% CI 5.21, 7.54) compared with those without maternal IBD, while offspring of mothers with IBD after childbirth had an adjusted HR of 3.88 (95% CI 3.27, 4.60). Corresponding adjusted HRs were 5.26 (95% CI 4.22, 6.56) among offspring with paternal IBD before childbirth and 3.73 (95% CI 3.10, 4.50) for paternal IBD after childbirth. Conclusion Offspring had a greater risk of IBD when either parent was diagnosed before childbirth rather than later, emphasising genetic predisposition and environmental risk factors rather than maternal inflammation in utero as risk factors for IBD.
引用
收藏
页码:206 / 213
页数:8
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