Polydopamine Nanoparticle-Based Combined Chemotherapy and Photothermal Therapy for the Treatment of Liver Cancer

被引：13

作者：

Emanet, Melis ^{[1
]}

Lefevre, Marie Celine ^{[1
]}

Ceccarelli, Maria Cristina ^{[1
,2
]}

Battaglini, Matteo ^{[1
]}

Carmignani, Alessio ^{[1
]}

Schiavone, Francesco ^{[1
]}

Marino, Attilio ^{[1
]}

De Pasquale, Daniele ^{[1
]}

Prato, Mirko ^{[3
]}

De Boni, Francesco ^{[3
]}

Petretto, Andrea ^{[4
]}

Bartolucci, Martina ^{[4
]}

Catalano, Federico ^{[5
]}

Moscato, Stefania ^{[6
]}

Ciofani, Gianni ^{[1
]}

机构：

[1] Ist Italiano Tecnol, Smart Biointerfaces, I-56025 Pontedera, Italy

[2] Scuola Super Sant Anna, BioRobot Inst, I-56025 Pontedera, Italy

[3] Ist Italiano Tecnol, Mat Characterizat Facil, I-16163 Genoa, Italy

[4] IRCCS Ist Giannina Gaslini, Core Facil Clin Proteom & Metabol, I-16147 Genoa, Italy

[5] Ist Italiano Tecnol, Electron Microscopy Facil, I-16163 Genoa, Italy

[6] Univ Pisa, Dept Clin & Expt Med, Via Roma 55, I-56126 Pisa, Italy

来源：

ACS APPLIED MATERIALS & INTERFACES | 2024年 / 16卷 / 31期

关键词：

polydopamine nanoparticles; homotypic targeting; sorafenib; photothermal therapy; liver cancer; HEPATOCELLULAR-CARCINOMA; CELL-CYCLE; SORAFENIB; PROTEIN; APOPTOSIS; SUPPRESSION; METASTASIS; ABLATION; PLATFORM; EVENTS;

D O I：

10.1021/acsami.4c08491

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Polydopamine nanoparticles (PDA NPs) are proposed as an anti-cancer tool against hepatocellular carcinoma through the combination of near-infrared (NIR)-mediated hyperthermia and loading with a chemotherapeutic drug, sorafenib (SRF). Cell membranes isolated from a liver cancer cell line (HepG2) have been exploited for the coating of the nanoparticles (thus obtaining CM-SRF-PDA NPs), to promote homotypic targeting toward cancer cells. The selective targeting ability and the combined photothermal and chemotherapeutic activity of the CM-SRF-PDA NPs following NIR irradiation have been evaluated on cell cultures in static and dynamic conditions, besides three-dimensional culture models. Eventually, the therapeutic effectiveness of the proposed approach has also been tested ex ovo on HepG2 spheroid-grafted quail embryos. This comprehensive investigation, supported by proteomic analysis, showed the effectiveness of the proposed nanoplatform and strongly suggests further pre-clinical testing in the treatment of liver cancer.

引用

页码：40695 / 40713

页数：19

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