Menopause could be involved in the pathogenesis of muscle and joint aches in mid-aged women

被引：32

作者：

Bluemel, Juan E. ^{[1
]}

Chedraui, Peter ^{[1
]}

Baron, German ^{[1
]}

Belzares, Emma ^{[1
]}

Bencosme, Ascanio ^{[1
]}

Calle, Andres ^{[1
]}

Danckers, Luis ^{[1
]}

Espinoza, Maria T. ^{[1
]}

Flores, Daniel ^{[1
]}

Gomez, Gustavo ^{[1
]}

Hernandez-Bueno, Jose A. ^{[1
]}

Izaguirre, Humberto ^{[1
]}

Leon-Leon, Patricia ^{[1
]}

Lima, Selva ^{[1
]}

Mezones-Holguin, Edward ^{[1
]}

Monterrosa, Alvaro ^{[1
]}

Mostajo, Desiree ^{[1
]}

Navarro, Daysi ^{[1
]}

Ojeda, Eliana ^{[1
]}

Onatra, William ^{[1
]}

Royer, Monique ^{[1
]}

Soto, Edwin ^{[1
]}

Tserotas, Konstantinos ^{[1
]}

Vallejo, Maria S. ^{[1
]}

机构：

[1] Univ Catolica Santiago Guayaquil, Inst Biomed, Fac Ciencias Med, Res Area Womens Hlth, Guayaquil, Ecuador

来源：

MATURITAS | 2013年 / 75卷 / 01期

关键词：

Muscle and joint aches; Menopause; Climacteric; Latin America; Vasomotor symptoms; QUALITY-OF-LIFE; MUSCULOSKELETAL PAIN; FIBROMYALGIA SYNDROME; REPLACEMENT THERAPY; SYMPTOMS; PREVALENCE; HEALTH; AMERICAN; MANAGEMENT; DURATION;

D O I：

10.1016/j.maturitas.2013.02.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Muscle and joint aches (MJA) are frequently observed among menopausal women. They impair quality of life and are a burden to the healthcare system. Objective: To analyze the relation between MJA and several variables related to the menopause. Methods: In this cross-sectional study, 8373 healthy women aged 40-59 years, accompanying patients to healthcare centers in 18 cities of 12 Latin American countries, were asked to fill out the Menopause Rating Scale (MRS) and a questionnaire containing personal data. Results: Mean age of the whole sample was 49.1 +/- 5.7 years, 48.6% were postmenopausal and 14.7% used hormone therapy (HT). A 63.0% of them presented MJA, with a 15.6% being scored as severe to very severe according to the MRS (scores 3 or 4). Logistic regression model determined that vasomotor symptoms (OR: 6.16; 95% CI, 5.25-7.24), premature menopause (OR: 1.58; 95% CI, 1.02-2.45), postmenopausal status (OR: 1.43; 95% CI, 1.20-1.69), psychiatric consultation (OR: 1.93; 95% CI, 1.60-2.32) and the use of psychotropic drugs (OR: 1.35; 95% CI, 1.08-1.69) were significantly related to the presence of severe-very severe MJA. Other significant variables included: age, tobacco consumption and lower education. Self perception of healthiness (OR: 0.49; 95% CI, 0.41-0.59), private healthcare access (OR: 0.77; 95% CI, 0.67-0.88) and HT use (OR: 0.75; 95% CI, 0.62-0.91) were significantly related to a lower risk for the presence of severe-very severe MJA. Conclusion: In this large mid-aged sample the prevalence of MJA was high, which was significantly associated to menopausal variables, especially vasomotor symptoms. This association may suggest a potential role of mid-life female hormonal changes in the pathogenesis of MJA. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：94 / 100

页数：7

共 47 条

[11] Severity of musculoskeletal pain: relations to socioeconomic inequality [J].