Advances in Developing Small Molecule Drugs for Alzheimer's Disease

被引：0
|
作者：
Zhang, Wei [1 ]
Zhang, Liujie [1 ]
Lv, Mingti [1 ,2 ]
Fu, Yun [1 ]
Meng, Xiaowen [1 ]
Wang, Mingyong [3 ,4 ]
Wang, Hecheng [1 ,5 ]
机构：
[1] Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang, Peoples R China
[2] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao, Peoples R China
[3] Xinxiang Med Univ, Sch Med Technol, Xinxiang, Peoples R China
[4] Shangqiu Med Coll, Dept Med Technol, Shangqiu, Henan, Peoples R China
[5] Dalin Univ Technol, Sch Life & Pharmaceut Sci, Panjin, Peoples R China
来源：
CURRENT ALZHEIMER RESEARCH | 2024年 / 21卷 / 04期
关键词：
Alzheime's disease; computer-aided drug design targets; beta-amyloid; forkhead box protein O1; small molecule drugs; DESIGN; IDENTIFICATION; INHIBITORS; DYNAMICS; FOXO1; QSAR; BETA;
D O I：
10.2174/0115672050329828240805074938
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Alzheimer's disease (AD) is the most common type of dementia among middle-aged and elderly individuals. Accelerating the prevention and treatment of AD has become an urgent problem. New technology including Computer-aided drug design (CADD) can effectively reduce the medication cost for patients with AD, reduce the cost of living, and improve the quality of life of patients, providing new ideas for treating AD. This paper reviews the pathogenesis of AD, the latest developments in CADD and other small-molecule docking technologies for drug discovery and development; the current research status of small-molecule compounds for AD at home and abroad from the perspective of drug action targets; the future of AD drug development.
引用
收藏
页码：221 / 231
页数：11
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