A planning study of proton therapy dose escalation for non-small cell lung cancer

被引：0

作者：

Hessels, Arno C. ^{[1
]}

Visser, Sabine ^{[1
]}

Both, Stefan ^{[1
]}

Korevaar, Erik W. ^{[1
]}

Langendijk, Johannes A. ^{[1
]}

Wijsman, Robin ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Groningen, Netherlands

来源：

PHYSICS & IMAGING IN RADIATION ONCOLOGY | 2024年 / 31卷

关键词：

Lung Cancer; Proton Therapy; Dose Escalation; Treatment Planning; RADIATION-THERAPY; TUMOR-CONTROL; RADIOTHERAPY; SURVIVAL;

D O I：

10.1016/j.phro.2024.100616

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In non-small-cell lung cancer (NSCLC), improving local control through radiotherapy dose escalation might improve survival. However, a photon-based RCT showed increased organ at risk dose exposure and worse overall survival in the dose escalation arm. In this study, intensity-modulated proton therapy plans with dose escalation to the primary tumour were created for 20 NSCLC patients. The mediastinal envelope was delineated to spare structures around the heart. It was possible to increase primary tumour dose up to 74.0 Gy without a significant increase in organ at risk doses and predicted toxicity.

引用

页数：5

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