Lipidomic analyses reveal potential biomarkers for predicting death and heart failure after acute myocardial infarction

被引：3
作者：
Guo, Chenglong [1 ]
Han, Xuexue [1 ]
Zhang, Tianxing [1 ]
Zhang, Hao [1 ]
Li, Xue [1 ]
Zhou, Xingzhu [1 ]
Feng, Shuhui [1 ]
Tao, Tianqi [2 ,3 ]
Yin, Chunlin [1 ]
Xia, Jinggang [1 ]
机构：
[1] Capital Med Univ, Xuanwu Hosp, Dept Cardiol, Beijing 100053, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Geriatr, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2024年 / 562卷
基金：
中国国家自然科学基金;
关键词：
Acute myocardial infarction; Death; Heart failure; Lipidomics; HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; PLASMALOGENS; HDL;
D O I：
10.1016/j.cca.2024.119892
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background Acute myocardial infarction (AMI) and postmyocardial infarction heart failure (pMIHF) have high mortality rates worldwide. This study aimed to explore lipidomic profiles and identify potential biomarkers for the prediction of death and heart failure (HF) after AMI. All serum samples were collected at Xuanwu Hospital, Capital Medical University, and their clinical characteristics and lipidomic profiles were analyzed in different groups. LC-MS/MS was used for lipidomic analyses, and underlying biomarkers were screened by receiver operating characteristic (ROC) curve analysis. Results Lipidomic analyses of the survival and nonsurvival groups revealed that the decrease of the content of SM (d18:1/22:0), PE (P-20:1/18:0), PC (18:2), LPE (18:2), PE (P-20:0/18:0), LPC (18:0) and PC (20:0/20:3) while increase of the content of PG (18:1/18:1) could increase the risk of death after AMI. In parallel, the lipidomic analysis of the HF and non-HF groups revealed that the decrease of the content of PC (20:3/20:4), LPC (20:3), LPC (18:0), LPC (18:2), LPC (20:0), LPC (18:3), LPE (16:1) and PC (18:2/20:3) could increase the risk of HF after AMI. Conclusion Several lipids could be potential biomarkers for the prediction of death and HF after AMI.
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页数：9
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