Growth differentiation factor 15: Emerging role in liver diseases

被引：4

作者：

Li, Yu ^{[1
]}

Zhang, Jie ^{[1
]}

Chen, Shurong ^{[1
]}

Ke, Yini ^{[2
]}

Li, Youming ^{[1
]}

Chen, Yi ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Gastroenterol, Hangzhou 310003, Peoples R China

[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Rheumatol, Hangzhou 310003, Peoples R China

来源：

CYTOKINE | 2024年 / 182卷

基金：

中国国家自然科学基金;

关键词：

GDF15; MASLD; MASH; Liver fibrosis; HCC; HEPATIC STELLATE CELLS; MACROPHAGE-INHIBITORY CYTOKINE; BETA SUPERFAMILY MEMBER; PROMOTES WEIGHT-LOSS; HEPATOCELLULAR-CARCINOMA; NAG-1/GDF15; EXPRESSION; ENERGY-EXPENDITURE; INSULIN-RESISTANCE; GAMMA LIGAND; GDF15;

D O I：

10.1016/j.cyto.2024.156727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growth differentiation factor 15 (GDF15) is a cell stress-response cytokine within the transforming growth factor-beta (TGF beta) superfamily. It is known to exert diverse effects on many metabolic pathways through its receptor GFRAL, which is expressed in the hindbrain, and transduces signals through the downstream receptor tyrosine kinase Ret. Since the liver is the core organ of metabolism, summarizing the functions of GDF15 is highly important. In this review, we assessed the relevant literature regarding the main metabolic, inflammatory, fibrogenic, tumorigenic and other effects of GDF15 on different liver diseases, including Metabolic dysfunctionassociated steatotic liver disease(MASLD), alcohol and drug-induced liver injury, as well as autoimmune and viral hepatitis, with a particular focus on the pathogenesis of MASLD progression from hepatic steatosis to MASH, liver fibrosis and even hepatocellular carcinoma (HCC). Finally, we discuss the prospects of the clinical application potential of GDF15 along with its research and development progress. With better knowledge of GDF15, increasing in-depth research will lead to a new era in the field of liver diseases.

引用

页数：9

共 141 条

[81]

Mieli-Vergani G, 2018, NAT REV DIS PRIMERS, V4, DOI [10.1038/nrdp.2018.18, 10.1038/nrdp.2018.17]

[82] Safety profile of autologous macrophage therapy for liver cirrhosis [J].

Moroni, Francesca ;

Dwyer, Benjamin J. ;

Graham, Catriona ;

Pass, Chloe ;

Bailey, Laura ;

Ritchie, Lisa ;

Mitchell, Donna ;

Glover, Alison ;

Laurie, Audrey ;

Doig, Stuart ;

Hargreaves, Emily ;

Fraser, Alasdair R. ;

Turner, Marc L. ;

Campbell, John D. M. ;

McGowan, Neil W. A. ;

Barry, Jacqueline ;

Moore, Joanna K. ;

Hayes, Peter C. ;

Leeming, Diana J. ;

Nielsen, Mette J. ;

Musa, Kishwar ;

Fallowfield, Jonathan A. ;

Forbes, Stuart J. .

NATURE MEDICINE, 2019, 25 (10) :1560-+

[83] GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates [J].

Mullican, Shannon E. ;

Lin-Schmidt, Xiefan ;

Chin, Chen-Ni ;

Chavez, Jose A. ;

Furman, Jennifer L. ;

Armstrong, Anthony A. ;

Beck, Stephen C. ;

South, Victoria J. ;

Dinh, Thai Q. ;

Cash-Mason, Tanesha D. ;

Cavanaugh, Cassandre R. ;

Nelson, Serena ;

Huang, Chichi ;

Hunter, Michael J. ;

Rangwala, Shamina M. .

NATURE MEDICINE, 2017, 23 (10) :1150-+

[84] Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination [J].

Myojin, Yuta ;

Hikita, Hayato ;

Tahata, Yuki ;

Doi, Akira ;

Kato, Seiya ;

Sasaki, Yoichi ;

Shirai, Kumiko ;

Sakane, Sadatsugu ;

Yamada, Ryoko ;

Kodama, Takahiro ;

Hagiwara, Hideki ;

Imai, Yasuharu ;

Hiramatsu, Naoki ;

Tamura, Shinji ;

Yamamoto, Keiji ;

Ohkawa, Kazuyoshi ;

Hijioka, Taizo ;

Fukui, Hiroyuki ;

Doi, Yoshinori ;

Yamada, Yukinori ;

Yakushijin, Takayuki ;

Mita, Eiji ;

Sakamori, Ryotaro ;

Tatsumi, Tomohide ;

Takehara, Tetsuo .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2022, 55 (04) :422-433

[85] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production [J].

Myojin, Yuta ;

Hikita, Hayato ;

Sugiyama, Masaya ;

Sasaki, Yoichi ;

Fukumoto, Kenji ;

Sakane, Sadatsugu ;

Makino, Yuki ;

Takemura, Nobuyuki ;

Yamada, Ryoko ;

Shigekawa, Minoru ;

Kodama, Takahiro ;

Sakamori, Ryotaro ;

Kobayashi, Shogo ;

Tatsumi, Tomohide ;

Suemizu, Hiroshi ;

Eguchi, Hidetoshi ;

Kokudo, Norihiro ;

Mizokami, Masashi ;

Takehara, Tetsuo .

GASTROENTEROLOGY, 2021, 160 (05) :1741-+

[86] Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist [J].

Nagase, I ;

Yoshida, T ;

Kumamoto, K ;

Umekawa, T ;

Sakane, N ;

Nikami, H ;

Kawada, T ;

Saito, M .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (12) :2898-2904

[87] Growth Differentiation Factor-15 and Risk of CKD Progression [J].

Nair, Viji ;

Robinson-Cohen, Cassianne ;

Smith, Michelle R. ;

Bellovich, Keith A. ;

Bhat, Zeenat Yousuf ;

Bobadilla, Maria ;

Brosius, Frank ;

de Boer, Ian H. ;

Essioux, Laurent ;

Formentini, Ivan ;

Gadegbeku, Crystal A. ;

Gipson, Debbie ;

Hawkins, Jennifer ;

Himmelfarb, Jonathan ;

Kestenbaum, Bryan ;

Kretzler, Matthias ;

Magnone, Maria Chiara ;

Perumal, Kalyani ;

Steigerwalt, Susan ;

Ju, Wenjun ;

Bansal, Nisha .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (07) :2233-2240

[88] NAFLD: Mechanisms, Treatments, and Biomarkers [J].

Nassir, Fatiha .

BIOMOLECULES, 2022, 12 (06)

[89] TGF-β contamination of purified recombinant GDF15 [J].

Olsen, Oddrun Elise ;

Skjaervik, Anette ;

Stordal, Berit Fladvad ;

Sundan, Anders ;

Holien, Toril .

PLOS ONE, 2017, 12 (11)

[90] Cloning and characterization of a novel member of the transforming growth factor-β/bone morphogenetic protein family [J].

Paralkar, VM ;

Vail, AL ;

Grasser, WA ;

Brown, TA ;

Xu, H ;

Vukicevic, S ;

Ke, HZ ;

Qi, H ;

Owen, TA ;

Thompson, DD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) :13760-13767

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