Identification of the allele HLA B*57:01 in a military population, from Lima-Peru

被引：0
|
作者：
Vilcarino-Zevallos, Giovanny [1 ]
Espetia-Anco, Susan [1 ]
Yaya-Rios, Mariela [1 ]
Cardenas-Bustamante, Fany [1 ]
Rodriguez-Bayona, Rafael [2 ]
Yabar-Varas, Carlos [1 ,3 ]
机构：
[1] Inst Nacl Salud, Ctr Nacl Salud Publ, Lima, Peru
[2] Hosp Mil Cent, Lima, Peru
[3] Univ San Martin Porres, Fac Med Humana, Lima, Peru
来源：
REVISTA CHILENA DE INFECTOLOGIA | 2024年 / 41卷 / 02期
关键词：
HLA B*57:01; HIV; abacavir; viral load; CD4 lymphocyte count; HIV genotyping; HIV-INFECTED PATIENTS; ABACAVIR HYPERSENSITIVITY REACTION; HLA-B-ASTERISK-5701; PHARMACOGENETICS; ASSOCIATION; PREVALENCE; FREQUENCY; THERAPY;
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The HLA B*57:01 allele is a genetic marker associated with hypersensitivity to the antiretroviral Abacavir (ABC) and its frequency in the Peruvian population is still unknown. The objective was to identify the HLA B*57:01 allele in a military population from Lima, Peru. Forty three people living with HIV (PLWH) were recruited, who agreed to participate through informed consent. Detection of the HLA B*57:01 allele was performed by real-time PCR (RT-PCR). Likewise, viral load (VL), CD4 lymphocyte count and HIV genotyping were determined. Two cases positive for the HLA B*57:01 allele (4.7%) were identified. In addition, one of them had multiple resistance mutations to antiretrovirals (ARVs), including ABC. The presence of the HLA B*57:01 allele was demonstrated for the first time in Peru.
引用
收藏
页码：311 / 315
页数：5
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