The role of epigenetics in women's reproductive health: the impact of environmental factors

被引：6
作者：
Yu, Xinru [1 ]
Xu, Jiawei [2 ]
Song, Bihan [2 ]
Zhu, Runhe [2 ]
Liu, Jiaxin [1 ]
Liu, Yi Fan [3 ]
Ma, Ying Jie [4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan, Shandong, Peoples R China
[2] Shandong Univ Tradit Chinese, Coll Tradit Chinese Med, Med Sch, Jinan, Shandong, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Med Coll, Jinan, Shandong, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Clin Coll 1, Jinan, Shandong, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷
关键词：
epigenetics; women; reproductive; environmental factors; reproductive health; DNA METHYLATION; CELL-GROWTH; STEM-CELLS; EXPRESSION; EXPOSURE; IMPLANTATION; ACETYLATION; MICRORNAS; ESTROGEN; EMBRYO;
D O I：
10.3389/fendo.2024.1399757
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This paper explores the significant role of epigenetics in women's reproductive health, focusing on the impact of environmental factors. It highlights the crucial link between epigenetic modifications-such as DNA methylation and histones post-translational modifications-and reproductive health issues, including infertility and pregnancy complications. The paper reviews the influence of pollutants like PM2.5, heavy metals, and endocrine disruptors on gene expression through epigenetic mechanisms, emphasizing the need for understanding how dietary, lifestyle choices, and exposure to chemicals affect gene expression and reproductive health. Future research directions include deeper investigation into epigenetics in female reproductive health and leveraging gene editing to mitigate epigenetic changes for improving IVF success rates and managing reproductive disorders.
引用
收藏
页数：23
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