Antidepressant-like and antioxidant effects of Morus nigra L. in rats subjected to the unpredictable chronic mild stress model

被引：1

作者：

Merida, Bruna Fischer ^{[1
]}

Dos Santos, Jessica Lima ^{[1
]}

Junges, Lucas Henrique ^{[2
]}

Zeni, Ana Lucia Bertarello ^{[3
]}

Da Silva, Eduardo Simao ^{[3
]}

机构：

[1] Univ Reg Blumenau, Dept Ciencias Saude, Blumenau, Brazil

[2] Univ Fed Parana, Dept Bioquim, Curitiba, Brazil

[3] Univ Reg Blumenau, Dept Ciencias Nat, Lab Avaliacao Subst Bioat, Blumenau, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

unpredictable chronic mild stress; oxidative stress; Morus nigra; OXIDATIVE STRESS; EXTRACT TREATMENT; LEAVES; PROFILE; MICE;

D O I：

10.1080/14786419.2024.2387253

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study aimed to evaluate the antidepressant-like and antioxidant potential of the aqueous leaf extract of Morus nigra L. in rats subjected to unpredictable chronic mild stress (UCMS). Male Wistar rats were divided into four groups, control and stressed, and treated with saline or aqueous extract of M. nigra. The dose administered was 10 mg/kg daily by gavage for 5 weeks concurrently with UCMS. M. nigra extract which showed syringic acid, quercetin, and rutin, as major phenolic compounds decreased the immobility time without changes in locomotor activity of stressed rats, in the forced swimming and open field tests, respectively. In addition, the extract diminished carbonylated proteins, lipid peroxidation, and nitrite levels in the brains of rats subjected to UCMS. These data reinforced antidepressant-like properties with the involvement of oxidative stress modulation by M. nigra extract pointing it as a possible new adjuvant treatment for depression. [GRAPHICS]

引用

页数：7

共 27 条

[1] Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors [J].

Anjomshoa, Maryam ;

Boroujeni, Shakiba Nasiri ;

Ghasemi, Sorayya ;

Lorigooini, Zahra ;

Amiri, Ahmad ;

Balali-dehkordi, Shima ;

Amini-khoei, Hossein .

BEHAVIOURAL NEUROLOGY, 2020, 2020

[2]

Araujo CM, 2015, FOOD FUNCT, V6, P3490, DOI [10.1039/C5FO00474H, 10.1039/c5fo00474h]

[3] Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder [J].

Behr, Guilherme A. ;

Moreira, Jose C. F. ;

Frey, Benicio N. .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2012, 2012

[4] Role of oxidative stress in depression [J].

Bhatt, Shvetank ;

Nagappa, Anantha Naik ;

Patil, Chandragouda R. .

DRUG DISCOVERY TODAY, 2020, 25 (07) :1270-1276

[5] A Synthesis of the Evidence for Managing Stress at Work: A Review of the Reviews Reporting on Anxiety, Depression, and Absenteeism [J].

Bhui, Kamaldeep S. ;

Dinos, Sokratis ;

Stansfeld, Stephen A. ;

White, Peter D. .

JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH, 2012, 2012

[6] Antioxidative enzyme activities and lipid peroxidation in major depression:: alterations by antidepressant treatments [J].

Bilici, M ;

Efe, H ;

Köroglu, MA ;

Uydu, HA ;

Bekaroglu, M ;

Deger, O .

JOURNAL OF AFFECTIVE DISORDERS, 2001, 64 (01) :43-51

[7] Chronic unpredictable stress impairs endogenous antioxidant defense in rat brain [J].

Che, Yi ;

Zhou, Zhu ;

Shu, Yuxin ;

Zhai, Chao ;

Zhu, Yuanyuan ;

Gong, Songjie ;

Cui, Yonghua ;

Wang, Jun-Feng .

NEUROSCIENCE LETTERS, 2015, 584 :208-213

[8] Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic syringic acid [J].

Dalmagro, Ana Paula ;

Camargo, Anderson ;

Pedron, Natalia B. ;

Garcia, Suliana A. M. ;

Zeni, Ana Lucia B. .

BEHAVIOURAL PHARMACOLOGY, 2020, 31 (04) :397-406

[9] Morus nigra and its major phenolic, syringic acid, have antidepressant-like and neuroprotective effects in mice [J].

Dalmagro, Ana Paula ;

Camargo, Anderson ;

Bertarello Zeni, Ana Lucia .

METABOLIC BRAIN DISEASE, 2017, 32 (06) :1963-1973

[10] Nitric oxide and major depression [J].

Dhir, Ashish ;

Kulkarni, S. K. .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2011, 24 (03) :125-131

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