Toward a paradigm shift in prognostication and treatment of early-stage Hodgkin lymphoma

Twenty years after the conceptual revolution that occurred in the millennium turnaround upon the introduction of PET/CT in lymphoma staging, restaging, and prognostication, a number of new parameters for PET reading have been proposed: (1) the shift from a qualitative to a semi-quantitative reading for PET reporting, (2) an international consensus on these novel interpretation keys, (3) a standardized and agreed procedure to measure the total metabolic tumour volume (TMTV), and (4) the proposition of new indexes to portray the tumour spread: (D-Max and Total Lesion Surface -TLS). These proved to be very powerful prognosticators, able to revolutionize the traditional Ann Arbor four-stage lymphoma staging. During the 17 degrees Lugano meeting on lymphoma, one main question was asked to experts attending a closed workshop dedicated to new metrics for lymphoma diagnosis, staging, restaging, and prognostication: "Should the traditional 4-stage anatomic staging system be simplified to a more clinically relevant 2-stage system (e.g., limited vs. extensive disease)?" Early-stage HL is an example of how these new metrics could fit with this proposal. Several new parameters related to (1) tumour burden, (2) tumour spread, (3) tumour chemosensitivity, (4) host response to treatment, and (5) minimal residual disease (MRD) assessment could revolutionize the standard treatment of early-stage Hodgkin Lymphoma, in a personalized-medicine approach. The RAFTING trial is an example of a multiparametric assessment of all these variables during and after treatment.image