The role of heat shock protein B8 in neuronal protection against oxidative stress and mitochondrial dysfunction: A literature review

被引：3

作者：

Wu, Yanqing ^{[1
]}

Xiong, Feng ^{[2
,3
]}

Ling, Jianmin ^{[2
,3
]}

机构：

[1] Wuhan Univ, Hlth Management Ctr, Renmin Hosp, Wuhan 430000, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Emergency Med, 1095 Jiefang Dadao, Wuhan 430000, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Crit Care Med, Wuhan 430000, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 140卷

关键词：

HSPB8; Neurological diseases; Mitochondria; Oxidative stress; Mitophagy; CHAPERONE COMPLEX; HSP22; HSPB8; OF-FUNCTION; MUTATIONS; KINASE; INJURY; H11; HOMEOSTASIS; INHIBITION; EXPRESSION;

D O I：

10.1016/j.intimp.2024.112836

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Excessive oxidative stress triggers cerebrovascular and neurodegenerative diseases resulting in acute and chronic brain injury. However, the underlying mechanisms remain unknown. Levels of small heat shock protein B8 (HSPB8), which is highly expressed in the brain, are known to be significantly elevated in cerebral injury models. Exogenous HSPB8 protects the brain against mitochondrial damage. One potential mechanism underlying this protection is that HSPB8 overexpression alleviates the mitochondria-dependent pathways of apoptosis; mitochondrial biogenesis, fission, and mitophagy. Overexpression of HSPB8 may therefore have potential as a clinical therapy for cerebrovascular and neurodegenerative diseases. This review provides an overview of advances in the protective effects of HSPB8 against excessive cerebral oxidative stress, including the modulation of mitochondrial dysfunction and potent signaling pathways.

引用

页数：7

共 95 条

[1] The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling [J].

Abdel-Nour, Mena ;

Carneiro, Leticia A. M. ;

Downey, Jeffrey ;

Tsalikis, Jessica ;

Outlioua, Ahmed ;

Prescott, Dave ;

Da Costa, Leandro Silva ;

Hovingh, Elise S. ;

Farahvash, Armin ;

Gaudet, Ryan G. ;

Molinaro, Raphael ;

van Dalen, Rob ;

Lau, Charles C. Y. ;

Azimi, Farshad C. ;

Escalante, Nichole K. ;

Trotman-Grant, Aaron ;

Lee, Jeffrey E. ;

Gray-Owen, Scott D. ;

Divangahi, Maziar ;

Chen, Jane-Jane ;

Philpott, Dana J. ;

Arnoult, Damien ;

Girardin, Stephen E. .

SCIENCE, 2019, 365 (6448) :47-+

[2] Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death [J].

Acunzo, Julie ;

Katsogiannou, Maria ;

Rocchi, Palma .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (10) :1622-1631

[3] Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases [J].

Adriaenssens, Elias ;

Geuens, Thomas ;

Baets, Jonathan ;

Echaniz-Laguna, Andoni ;

Timmerman, Vincent .

BRAIN, 2017, 140 :2541-2549

[4] Mitochondria in Health and Disease [J].

Annesley, Sarah J. ;

Fisher, Paul R. .

CELLS, 2019, 8 (07)

[5] Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats [J].

Bartelt-Kirbach, Britta ;

Slowik, Alexander ;

Beyer, Cordian ;

Golenhofen, Nikola .

CELL STRESS & CHAPERONES, 2017, 22 (04) :653-663

[6] Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies [J].

Bhatti, Jasvinder Singh ;

Bhatti, Gurjit Kaur ;

Reddy, P. Hemachandra .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (05) :1066-1077

[7] A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8 [J].

Bouhy, Delphine ;

Juneja, Manisha ;

Katona, Istvan ;

Holmgren, Anne ;

Asselbergh, Bob ;

De Winter, Vicky ;

Hochepied, Tino ;

Goossens, Steven ;

Haigh, Jody J. ;

Libert, Claude ;

Ceuterick-de Groote, Chantal ;

Irobi, Joy ;

Weis, Joachim ;

Timmerman, Vincent .

ACTA NEUROPATHOLOGICA, 2018, 135 (01) :131-148

[8] Ischaemic stroke [J].

Campbell, Bruce C., V ;

De Silva, Deidre A. ;

Macleod, Malcolm R. ;

Coutts, Shelagh B. ;

Schwamm, Lee H. ;

Davis, Stephen M. ;

Donnan, Geoffrey A. .

NATURE REVIEWS DISEASE PRIMERS, 2019, 5 (1)

[9] Failure of collateral blood flow is associated with infarct growth in ischemic stroke [J].

Campbell, Bruce C. V. ;

Christensen, Soren ;

Tress, Brian M. ;

Churilov, Leonid ;

Desmond, Patricia M. ;

Parsons, Mark W. ;

Barber, P. Alan ;

Levi, Christopher R. ;

Bladin, Christopher ;

Donnan, Geoffrey A. ;

Davis, Stephen M. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (08) :1168-1172

[10] The stress-inducible HspB8-Bag3 complex induces the eIF2α kinase pathway Implications for protein quality control and viral factory degradation? [J].

Carra, Serena .

AUTOPHAGY, 2009, 5 (03) :428-429

← 1 2 3 4 5 6 7 8 9 10 →