Characteristics of Rheumatic Diseases in the Elderly

被引：0

作者：

Schultz, Olaf ^{[1
]}

机构：

[1] ACURA Rheumazentrum Baden Baden, Rheumatology, Rotenbachtalstr 5, D-76530 Baden Baden, Germany

来源：

AKTUELLE RHEUMATOLOGIE | 2024年 / 49卷 / 05期

关键词：

rheumatic diseases; elderly; old; multimorbidity; late-onset; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CLINICAL-FEATURES; PSORIATIC-ARTHRITIS; ONSET; OLDER; YOUNGER; AGE; COMORBIDITIES; VASCULITIS; MORTALITY;

D O I：

10.1055/a-2349-3860

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological data suggests a global rise of rheumatic diseases in elderly individuals due to increased life expectancy. Unfortunately, the life span is not synonymous with the health span, so this population is significantly affected by an increased risk for cardiovascular, malignant, infectious and iatrogenic complications. Comorbidities, polypharmacy and progressive functional decline culminating in geriatric syndromes have an impact on the clinical course and therapeutic strategy in older patients with rheumatic diseases. The aged immune system is compromised by immunosenescence and inflammaging leading to attenuated protective immunity, resilience and regenerative potential as well as increased systemic inflammation. In addition to the few age-related rheumatic diseases such as polymyalgia rheumatica, there are age-specific forms of rheumatic diseases with unique characteristics regarding clinical symptoms, pathophysiology, laboratory diagnostics, and prognosis. Elderly-onset rheumatic diseases often exhibit distinct clinical, pathophysiological and diagnostic features. Atypical variants and overlapping manifestations with degenerative or inflammatory diseases complicate the diagnostic attribution. This review provides a comprehensive overview and presents specific aspects of the most relevant rheumatic diseases in the elderly.

引用

页码：291 / 300

页数：10

共 73 条

[1] Comparison of late-onset and non-late-onset systemic lupus erythematosus individuals in a real-world electronic health record cohort [J].

Adeogun, Ganiat ;

Camai, Alex ;

Suh, Ashley ;

Wheless, Lee ;

Barnado, April .

LUPUS, 2024, 33 (05) :525-531

[2]

[Anonymous], About Us

[3] Association of age with the non-achievement of clinical and functional remission in rheumatoid arthritis [J].

Aoki, Tadashi ;

Ito, Hideki ;

Ogura, Takehisa ;

Hirata, Ayako ;

Nishiwaki, Yuji ;

Kameda, Hideto .

SCIENTIFIC REPORTS, 2020, 10 (01)

[4] Getting older with rheumatoid arthritis-is there a burnout of the disease? [J].

Bauhammer, J. ;

Fiehn, C. .

ZEITSCHRIFT FUR RHEUMATOLOGIE, 2018, 77 (05) :355-362

[5] Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease [J].

Beck, David B. ;

Ferrada, Marcela A. ;

Sikora, Keith A. ;

Ombrello, Amanda K. ;

Collins, Jason C. ;

Pei, Wuhong ;

Balanda, Nicholas ;

Ross, Daron L. ;

Ospina Cardona, Daniela ;

Wu, Zhijie ;

Patel, Bhavisha ;

Manthiram, Kalpana ;

Groarke, Emma M. ;

Gutierrez-Rodrigues, Fernanda ;

Hoffmann, Patrycja ;

Rosenzweig, Sofia ;

Nakabo, Shuichiro ;

Dillon, Laura W. ;

Hourigan, Christopher S. ;

Tsai, Wanxia L. ;

Gupta, Sarthak ;

Carmona-Rivera, Carmelo ;

Asmar, Anthony J. ;

Xu, Lisha ;

Oda, Hirotsugu ;

Goodspeed, Wendy ;

Barron, Karyl S. ;

Nehrebecky, Michele ;

Jones, Anne ;

Laird, Ryan S. ;

Deuitch, Natalie ;

Rowczenio, Dorota ;

Rominger, Emily ;

Wells, Kristina V. ;

Lee, Chyi-Chia R. ;

Wang, Weixin ;

Trick, Megan ;

Mullikin, James ;

Wigerblad, Gustaf ;

Brooks, Stephen ;

Dell'Orso, Stefania ;

Deng, Zuoming ;

Chae, Jae J. ;

Dulau-Florea, Alina ;

Malicdan, May C. V. ;

Novacic, Danica ;

Colbert, Robert A. ;

Kaplan, Mariana J. ;

Gadina, Massimo ;

Savic, Sinisa .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2628-2638

[6] Disease and treatment-related morbidity in young and elderly patients with granulomatosis with polyangiitis and microscopic polyangiitis [J].

Berti, Alvise ;

Felicetti, Mara ;

Monti, Sara ;

Ortolan, Augusta ;

Padoan, Roberto ;

Brunori, Giuliano ;

Bortolotti, Roberto ;

Caporali, Roberto ;

Montecucco, Carlomaurizio ;

Schiavon, Franco ;

Paolazzi, Giuseppe .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2020, 50 (06) :1441-1448

[7] Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial [J].

Boers, Maarten ;

Hartman, Linda ;

Opris-Belinski, Daniela ;

Bos, Reinhard ;

Kok, Marc R. ;

Da Silva, Jose A. P. ;

Griep, Eduard N. ;

Klaasen, Ruth ;

Allaart, Cornelia F. ;

Baudoin, Paul ;

Raterman, Hennie G. ;

Szekanecz, Zoltan ;

Buttgereit, Frank ;

Masaryk, Pavol ;

Klausch, L. Thomas ;

Paolino, Sabrina ;

Schilder, Annemarie M. ;

Lems, Willem F. ;

Cutolo, Maurizio .

ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (07) :925-936

[8] The influence of ageing on the development and management of rheumatoid arthritis [J].

Boots, Annemieke M. H. ;

Maier, Andrea B. ;

Stinissen, Piet ;

Masson, Pierre ;

Lories, Rik J. ;

De Keyser, Filip .

NATURE REVIEWS RHEUMATOLOGY, 2013, 9 (10) :604-613

[9] Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic Lupus erythematosus [J].

Cartella, Stefania ;

Cavazzana, Ilaria ;

Ceribelli, Angela ;

Inverardi, Flora ;

Tincani, Angela ;

Franceschini, Franco .

AUTOIMMUNITY, 2013, 46 (06) :363-368

[10] Proinflammatory Cytokine Profiles of Patients with Elderly-Onset Rheumatoid Arthritis: A Comparison with Younger-Onset Disease [J].

Chen, Der-Yuan ;

Hsieh, Tsu-Yi ;

Chen, Yi-Ming ;

Hsieh, Chia-Wie ;

Lan, Joung-Liang ;

Lin, Fang-Ju .

GERONTOLOGY, 2009, 55 (03) :250-258

← 1 2 3 4 5 6 7 8 →