Palladium-Catalyzed C(sp3)-Si Bonds Transformation for Constructing Trifluoropropyl (Hetero)arenes through C(sp3)-C(sp2) Cross-Coupling Reactions

被引：0
作者：
Liu Junjun [1 ]
Lu Taotao [1 ]
Ma Ping [1 ]
Zhao Qingyang [1 ]
Yee, Kwong Fuk [2 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen Campus, Shenzhen 518107, Guangdong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 04期
关键词：
palladium catalysis; Hiyama cross-coupling reaction; fluoroalkylation; organosilicon; PROMOTED TRIFLUOROMETHYLATION; ORGANOSILICON COMPOUNDS; ARYL; METHYLATION; ACTIVATION; FLUORINE; ALKENES; ALKYNES; TRENDS; SALTS;
D O I：
10.6023/cjoc202310013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed C(sp(3))- Si bonds transformation of commercially available polyalkoxy trifluorosilane reagents has been developed through C(sp(3))-C(sp(2)) cross-coupling reactions. This Hiyama cross-coupling reaction shows good functional group tolerance and provides a series of trifluoropropyl (hetero)arenes. The fluoride source and alkyl tether of bisphosphine ligand play important roles in improving yields.
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页码：1319 / 1326
页数：8
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